艾司氯胺酮联合苯磺酸瑞马唑仑对ERCP患者影响的meta分析  

Meta-analysis on effect of esketamine in combination with remazolam besylate for patients taking endoscopic retrograde cholangiopancreatography

作　　者：司文丽 张全意[1] Si Wenli;Zhang Quanyi(Department of Anesthesiology,Binzhou Medical University Hospital,Binzhou 256600,China)

机构地区：[1]滨州医学院附属医院麻醉科,滨州256600

出　　处：《国际医药卫生导报》2024年第7期1099-1104,共6页International Medicine and Health Guidance News

基　　金：滨州医学院附属医院科研创新团队(滨附行发[2020]31号)。

摘　　要：目的系统评价艾司氯胺酮与苯磺酸瑞马唑仑联合使用对内镜逆行胰胆管造影术(ERCP)患者的影响。方法检索中国知网、维普、万方、PubMed、Web of science、Embase及Cochrance图书馆的数据库,从建库到2023年3月发表的艾司氯胺酮联合苯磺酸瑞马唑仑用于ERCP的随机对照试验(RCTs)。试验组采用艾司氯胺酮复合苯磺酸瑞马唑仑的麻醉方案,对照组采用其他静脉麻醉药物联合使用方案。由互不关联的2名研究者根据纳入排除标准对文献进行仔细筛选,使用Review Manager 5.4软件进行统计分析。结果纳入6项RCTs,共532例患者。与其他麻醉药物联合使用方案比较,艾司氯胺酮联合苯磺酸瑞马唑仑组患者发生低血压、呼吸抑制等不良事件的概率更低(RR=0.29,95%CI 0.17~0.50;RR=0.18,95%CI 0.08~0.38)。结论采用艾司氯胺酮联合苯磺酸瑞马唑仑能减少患者ERCP中的不良事件发生概率,是一种更平稳、安全的麻醉方法。Objective To systematically review the effect of esketamine in combination with remazolam besylate for patients taking endoscopic retrograde cholangiopancreatography(ERCP).Methods The randomized controlled trials(RCTs)on esketamine and remimazolam besylate for patients taking ERCP published at CNKI,VIP,Wanfang,PubMed,Web of Science,Embase,and the Cochrance Library from their establishment to March 2023 were searched.The experimental group was anesthetized with the combination of ketamine and remifentanil besylate for ERCP,while the control group with other intravenous anesthetics.Two unrelated researchers carefully screened the literatures based on the inclusion and exclusion criteria,and conducted statistical analysis using the Review Manager 5.4 software.Results Six RCTs were included,with a total of 532 patients.Compared with other anesthesia drug regimens,the esketamine combined with remazolam besylate group had lower probabilities of hypotension and respiratory depression(RR=0.29,95%CI 0.17~0.50;RR=0.18,95%CI 0.08~0.38).Conclusion The combined use of ketamine and remazolam besylate for patients taking ERCP can significantly reduce the probability of adverse events,and is a more stable and safer anesthesia method.

关 键 词：内镜逆行胰胆管造影术 苯磺酸瑞马唑仑 艾司氯胺酮 META分析 

分 类 号：R614[医药卫生—麻醉学]