血尿酸水平与高血压患者颈动脉内-中膜厚度的相关性分析  

Correlation analysis between serum uric acid and carotid intima-media thickness in patientswith hypertension

作　　者：屈文涛 黄勋 王琳 Qu Wentao;Huang Xun;Wang Lin(Department of Ultrasound,Xi'an Hospital of Traditional Chinese Medicine,Xi'an 710021,China;Department of Vascular Surgery,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China;Department of Critical Medicine,Xi'an Hospital of Traditional Chinese Medicine,Xi'an 710021,China)

机构地区：[1]西安市中医医院超声科,西安710021 [2]西安交通大学第一附属医院血管外科,西安710061 [3]西安市中医医院重症医学科,西安710021

出　　处：《国际医药卫生导报》2024年第8期1330-1333,共4页International Medicine and Health Guidance News

基　　金：陕西省重点研发计划(S2021-YF-YBSF-0796)。

摘　　要：目的探讨高血压患者血尿酸(SUA)水平与颈动脉内-中膜厚度(CIMT)的相关性。方法采用回顾性研究,选取西安市中医医院2020年3月至10月被诊断为高血压的患者110例。其中,单纯高血压患者60例[HT组,男31例,女29例,年龄(51.59±10.84)岁],高血压合并高尿酸血症者50例[HT+HU组,男23例,女27例,年龄(52.27±10.12)岁]。另外,选取健康体检者40名[健康对照组,男20例,女20例,年龄(51.23±9.43)岁]。比较各组之间的血压、体重指数(BMI)、甘油三酯、总胆固醇、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、SUA、CIMT的差异,分析SUA水平与CIMT的相关性。统计学方法采用单因素方差分析、χ^(2)检验、偏相关分析、多元线性回归分析。结果3组之间性别、年龄、心率、吸烟、总胆固醇、甘油三酯、HDL-C、LDL-C比较,差异均无统计学意义(均P>0.05);HU+HT组SUA水平高于对照组与HT组[(496.52±74.82)µmol/L比(253.42±80.46)µmol/L比(267.78±75.72)µmol/L],差异有统计学意义(F=156.14,P<0.05);HT组与HU+HT组的收缩压、舒张压均高于对照组[(164.72±12.86)mmHg(1mmHg=0.133kPa)比(165.87±12.96)mmHg比(106.75±7.46)mmHg、(98.82±6.56)mmHg比(98.78±6.85)mmHg比(73.68±4.66)mmHg],差异均有统计学意义(F=366.07、239.34,均P<0.05);HU+HT组与HT组的CIMT均高于对照组,HU+HT组高于HT组与对照组[(1.02±0.18)mm比(0.85±0.19)mm比(0.60±0.11)mm],差异有统计学意义(F=68.95,P<0.05)。偏相关分析显示,HU+HT组患者的SUA水平与CIMT水平正相关(r=0.42,P<0.05)。多因素线性回归分析显示,SUA水平是高血压患者CIMT的独立影响因素(P<0.05)。结论高血压合并高尿酸血症患者的CIMT增厚显著,高血压患者SUA水平与CIMT密切相关,当高血压患者合并高尿酸血症时,进一步加重了动脉粥样硬化等心血管疾病的进程。Objective To analyze the relationship between serum uric acid(SUA)and carotid intima-media thickness(CIMT)in patients with hypertension.Methods A retrospective study was conducted to select 110 patients diagnosed with hypertension in Xi'an Hospital of Traditional Chinese Medicine from March to October 2020. Among them, there were 60 patients withsimple hypertension [HT group, 31 males and 29 females, aged (51.59±10.84) years] and 50 patientswith hypertension combined with hyperuricemia [HT+HU group, 23 males and 27 females, aged(52.27±10.12) years]. In addition, 40 healthy adults were selected [healthy control group, 20 malesand 20 females, aged (51.23±9.43) years]. The differences of blood pressure, body mass index (BMI),triglyceride, total cholesterol, high density lipoprotein cholesterol (HDL-C), low density lipoproteincholesterol (LDL-C), SUA, and CIMT among all the groups were compared, and the correlationbetween SUA and CIMT was analyzed. The statistical methods were one-way ANOVA, χ^(2) test, partialcorrelation analysis, and multiple linear regression analysis. Results There were no statisticallysignificant differences in the gender, age, heart rate, smoking, total cholesterol, triglyceride, HDL-C,and LDL-C among the 3 groups (all P>0.05). The SUA level in the HU+HT group was higher than thatin the control group and the HT group [(496.52±74.82) μmol/L vs. (253.42±80.46) μmol/L vs.(267.78±75.72) μmol/L], with a statistically significant difference (F=156.14, P<0.05). The systolicblood pressure and diastolic blood pressure in the HT group and the HU+HT group were higher thanthose in the control group [(164.72±12.86) mmHg (1 mmHg=0.133 kPa) vs. (165.87±12.96) mmHgvs. (106.75±7.46) mmHg, (98.82±6.56) mmHg vs. (98.78±6.85) mmHg vs. (73.68±4.66) mmHg], withstatistically significant differences (F=366.07 and 239.34, both P<0.05). The CIMT of the HU+HTgroup and the HT group were higher than that of the control group, and the CIMT of the HU+HT groupwas higher than those of the HT group and the contr

关 键 词：高血压 高尿酸血症 血尿酸 颈动脉内-中膜厚度 动脉粥样硬化 心血管疾病 

分 类 号：R544.1[医药卫生—心血管疾病]