中医穴位定向透药对糖尿病足临床证候及踝肱指数的影响  

Effects of acupoint directed penetration of traditional Chinese medicine on clinical symptoms and ankle-brachial index of diabetic foot

作　　者：王慧 庞宏永[1] 陈明环[1] 王倩[1] 刘平[1] WANG Hui;PANG Hongyong;CHEN Minghuan;WANG Qian;LIU Ping(Department of Traditional Chinese Medicine Surgery,Shangqiu First People′s Hospital,Shangqiu 476100,China)

机构地区：[1]商丘市第一人民医院中医外科,商丘476100

出　　处：《华夏医学》2024年第1期202-207,共6页Acta Medicinae Sinica

基　　金：河南省医学科技攻关项目(LHGJ2021014321)。

摘　　要：目的观察中医穴位定向透药对改善糖尿病足患者临床证候及踝肱指数(ABI)的影响。方法选取商丘市第一人民医院2021年1月至2023年1月收治的121例糖尿病足患者为研究对象,采用抽签法分为观察组(n=70)和对照组(n=51)。对照组予以常规西药治疗,观察组采用中医穴位定向透药联合西药治疗,比较两组疗效,分析ABI指数与治疗效果间的相关性。结果治疗后,观察组的中医主证积分、中医次证积分、C-反应蛋白(CRP)水平低于对照组,胰岛素生长因子-1(IGF-1)、胰岛素生长因子-2(IGF-2)水平高于对照组,差异均具有统计学意义(P<0.05)。治疗3 d、7 d、14 d后,观察组的ABI指数均高于对照组(P<0.05)。经Spearman相关性系数检验,ABI与中医主证积分、中医次证积分、CRP水平负相关,与IGF-1、IGF-2水平正相关。结论中医穴位定向透药可改善糖尿病足临床证候及ABI指数。Objective To observe the effect of acupoint directed penetration of traditional Chinese medicine(TCM)on improving clinical symptoms and ankle-brachial index(ABI)of patients with diabetic foot.Methods 121 patients with diabetic foot admitted to the First People′s Hospital of Shangqiu City from January 2021 to January 2023 were included in this study.The patients were divided into two groups by lot drawing,the combined group(n=70)and the control group(n=51).The control group were treated with conventional Western medicine,while the combination group were treated with acupoint directed penetration of TCM;symptom points with Western medicine.The therapeutic effects of the two groups were compared,and the correlation between ABI index and patient treatment effectiveness was analyzed.Results After treatment,the main and secondary syndrome scores,C-reactive protein(CRP)of the combined group were lower than those of the control group;insulin-like growth factor 1(IGF-1)and insulin-like growth factor 2(IGF-2)were both higher than those in the control group,with a statistically significant difference(P<0.05).The ABI index of the combination group after 3,7,and 14 of treatment was higher than that of the control group(P<0.05).According to Spearman correlation coefficient test,ABI is negatively correlated with TCM main syndrome,TCM secondary syndrome score,and CRP level,while positively correlated with IGF-1 and IGF-2 levels.Conclusion Acupoint directed penetration of TCM can improve the clinical symptoms and ABI index of Diabetic foot.

关 键 词：糖尿病足 中医穴位定向透药 证候积分 踝肱指数 

分 类 号：R259[医药卫生—中西医结合]