血清一氧化氮、一氧化氮合酶预测良性前列腺增生术后患者勃起功能障碍的研究  

Study on serum nitric oxide and nitric oxide synthase in predicting erectile dysfunction in patients with benign prostatic hyperplasia after surgery

作　　者：杨林杰 王艳华 YANG Linjie;WANG Yanhua(Department of Urology,the Second People′s Hospital of Jiashan County,Zhejiang,Jiaxing 314100,Zhejiang,China;Department of Urology,Ganzhou People′s Hospital,Ganzhou 341099,Jiangxi,China)

机构地区：[1]浙江省嘉善县第二人民医院泌尿外科,浙江嘉兴314100 [2]赣州市人民医院泌尿外科,江西赣州341099

出　　处：《中国性科学》2024年第4期13-16,共4页Chinese Journal of Human Sexuality

摘　　要：目的探讨血清一氧化氮(NO)、一氧化氮合酶(NOS)对良性前列腺增生(BPH)术后患者勃起功能障碍的预测价值。方法选取2020年3月至2022年10月浙江省嘉善县第二人民医院收治的86例拟行手术治疗的BPH患者作为研究对象。于术后7 d内检测患者血清NO、NOS水平,术后6个月评估勃起功能障碍发生情况,分析血清NO、NOS预测BPH术后患者勃起功能障碍的临床价值。结果86例BPH患者术后勃起功能障碍发生率为47.67%(41/86)。发生组、未发生组国际前列腺症状评分(IPSS)、血清前列腺素E_(2)水平比较,差异具有统计学意义(P<0.05)。术后7 d,发生组血清NO、NOS水平低于术前,且低于未发生组(P<0.05)。Logistic回归分析显示,BPH术后患者勃起功能障碍发生的影响因素为IPSS高,血清NO、NOS及前列腺素E_(2)水平低(P<0.05)。绘制受试者工作特征(ROC)曲线发现,NO、NOS单独及联合预测BPH术后患者勃起功能障碍的曲线下面积(AUC)分别为0.808、0.837和0.887,均具有一定的预测价值,其中联合预测效能最佳。结论血清NO、NOS预测BPH术后患者勃起功能障碍具有良好的临床价值。Objective To explore the predictive value of serum nitric oxide(NO)and nitric oxide synthase(NOS)on erectile dysfunction in patients with benign prostatic hyperplasia(BPH)after surgery.Methods A total of 86 patients with BPH who were scheduled to undergo surgical treatment in the Second People′s Hospital of Jiashan County,Zhejiang from March 2020 to October 2022 were selected as study objects.Serum NO and NOS levels were detected in all patients within 7 days after surgery.The incidence of erectile dysfunction was evaluated 6 months after surgery.The clinical value of serum NO and NOS in predicting erectile dysfunction in patients with BPH after surgery was analyzed.Results The incidence of postoperative erectile dysfunction in 86 BPH patients was 47.67%(41/86).There were significant differences in international prostate symptom score(IPSS)and serum prostaglandin E_(2)level between the occurrence group and the non-occurrence group(P<0.05).On the 7 days after surgery,the serum NO and NOS levels in the occurrence group were lower than before surgery and lower than those in the non-occurrence group(P<0.05).Logistic regression analysis showed that the influencing factors of erectile dysfunction in patients with BPH after surgery were high IPSS and low levels of serum NO,NOS and prostaglandin E_(2)(P<0.05).Plotting receiver operating characteristic(ROC)curve showed that the area under the curve(AUC)of NO,NOS alone and their combination in predicting erectile dysfunction in patients with BPH after surgery were 0.808,0.837 and 0.887,respectively,which had certain predictive value.Among them,the combined prediction was the best.Conclusions Serum NO and NOS have good clinical value in predicting erectile dysfunction in patients with BPH after surgery.

关 键 词：良性前列腺增生 勃起功能障碍 一氧化氮 一氧化氮合成酶 

分 类 号：R697[医药卫生—泌尿科学]