NOS3、IL-1β基因多态性与不明原因复发性流产相关性的研究进展  

Research progress of nitric oxide synthase 3 and interleukin-1βgene polymorphisms and unexplained recurrent spontaneous abortion

作　　者：丁仲军 毛宝宏[2] 倪亚莉[1] 许文婧 刘青[3] DING Zhongjun;MAO Baohong;NI Yali;XU Wenjing;LIU Qing(Reproductive Medical Center,Gansu Provincial Maternity and Child Care Hospital,Lanzhou 730050,Gansu,China;Research Institute of Clinical Medical Science,Gansu Provincial Maternity and Child Care Hospital,Lanzhou 730050,Gansu,China;Department of Gynecology with Integrated Traditional Chinese and Western Medicine,Gansu Provincial Maternity and Child Care Hospital,Lanzhou 730050,Gansu,China)

机构地区：[1]甘肃省妇幼保健院(甘肃省中心医院)生殖医学中心,兰州730050 [2]甘肃省妇幼保健院(甘肃省中心医院)科研中心,兰州730050 [3]甘肃省妇幼保健院(甘肃省中心医院)中西医结合妇科,兰州730050

出　　处：《中国性科学》2024年第4期66-70,共5页Chinese Journal of Human Sexuality

基　　金：甘肃省国际科技合作项目(22YF7WA091)。

摘　　要：不明原因复发性流产(URSA)是妇产科中最常见的妊娠并发症之一,给患者身心和家庭造成严重的负面影响,是育龄期女性生殖健康的一大威胁。其病因及发病机制不清,尚无有效的防治措施,是当前生殖健康领域的一大难点。有研究表明一氧化氮合酶3(NOS3)、白介素-1β(IL-1β)基因的相关功能区单核苷酸多态性(SNP)与URSA疾病相关,但文献结果并不一致。本文就NOS3、IL-1β基因多态性与URSA相关性的研究进展进行综述。Unexplained recurrent spontaneous abortion(URSA)is one of the most common pregnancy complications in obstetrics and gynecology,which causes serious negative effects on the patient′s body,mind and family,and is a major threat to the reproductive health of women of childbearing age.The etiology and pathogenesis of URSA are still unclear,and there is no effective prevention and treatment measures,which is a major difficulty in the field of reproductive health.Studies have shown that single nucleotide polymorphism(SNP)in nitric oxide synthase 3(NOS3)and interleukin 1β(IL-1β)genes are associated with URSA,but the literature results are not consistent.This article reviews the research progress on the correlation between NOS3,IL-1βgene polymorphisms and URSA.

关 键 词：一氧化氮合酶3 白介素-1Β 基因多态性 复发性流产 

分 类 号：R714[医药卫生—妇产科学]