基于氧化应激从祛瘀解毒法论治子宫内膜异位症患者在位内膜容受性不良  

Treatment variation of endometriosis patients with poor endometrial receptivity by Quyu Jiedu method based on oxidative stress

作　　者：杨思晨 王玲[2] 高路益 孙新慧 张悦健 马小娜 YANG Sichen;WANG Ling;GAO Luyi;SUN Xinhui;ZHANG Yuejian;MA Xiaona(The Third Clinical Medical College of Beijing University of Chinese Medicine,Beijing 100029,China;Department of TCM Gynecology,Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University,Hangzhou 310053,Zhejiang,China;Department of Gynecology,the Third Affiliated Hospital of Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学第三临床医学院,北京100029 [2]浙江中医药大学附属杭州市中医院中医妇科,杭州310053 [3]北京中医药大学第三附属医院妇科,北京100029

出　　处：《中国性科学》2024年第4期131-136,共6页Chinese Journal of Human Sexuality

基　　金：国家自然科学基金项目(81973895);北京中医药大学重点攻关项目(2020-JYB-ZDGG-143-3);第五批全国中医临床优秀人才研修项目(国中医药人教函〔2022〕1号)。

摘　　要：氧化应激(OS)是子宫内膜异位症(EMs)患者出现在位内膜容受性不良的重要原因之一,调节OS可能是治疗该疾病关键。从中医视角而言,“血瘀蕴毒”理论与EMs患者体内OS发生关系密切,因而以祛瘀解毒为治疗原则,旨在下调EMs患者体内OS反应,从而改善子宫内膜容受性,提高临床妊娠率。琥珀散组方遵循祛瘀解毒原则,通过生物信息学分析,从基因层面揭示该方以OS调治本病的潜在分子机制,进一步验证核心思想,以期为该疾病治疗提供参考。Oxidative stress(OS)is one of the key causes of poor endometrial receptivity in patients with endometriosis(EMs),and regulating the OS may be the key for the treatment of this disease.From the perspective of traditional Chinese medicine,the theory of"stasis-toxic"is closely related to the occurrence of OS in EMs patients,so the basic treatment principle is Quyu Jiedu(QYJD,a method for removing stasis and detoxicating),aiming to reduce OS response in EMs patients,thereby improving endometrial receptivity and increasing clinical pregnancy rate.Amber powder formula follows the principle of QYJD revealed the underlying molecular mechanism of OS treatment from the genetic level through bioinformatics analysis,which further verifies the core idea of this study,in order to provide reference for the treatment of this disease.

关 键 词：子宫内膜异位症 子宫内膜容受性 祛瘀解毒 氧化应激 生物信息学 

分 类 号：R275[医药卫生—中医皮科]