寿胎丸加减联合黄体酮注射液对早期肾虚型先兆流产患者疗效、性激素及血清IL-2、IL-6、CRP水平的影响  

Influences of modified Shoutai Pill combined with progesterone injection on curative effect,sex hormones,serum interleukin-2,interleukin-6 and C-reactive protein levels in patients with early threatened abortion of kidney deficiency type

作　　者：刁玉芳 宋香金 刘芬 姜天凤 谢运 DIAO Yufang;SONG Xiangjin;LIU Fen;JIANG Tianfeng;XIE Yun(Department of Gynecology,Taihe Traditional Chinese Medicine Hospital Affiliated to Anhui University of Traditional Chinese Medicine,Fuyang 236600,Anhui,China)

机构地区：[1]安徽中医药大学附属太和中医院妇科,安徽阜阳236600

出　　处：《中国性科学》2024年第4期140-144,共5页Chinese Journal of Human Sexuality

基　　金：2020年安徽中医药大学科研项目(2020thzy014)。

摘　　要：目的探讨寿胎丸加减联合黄体酮注射液对早期肾虚型先兆流产患者疗效、性激素及血清白介素-2(IL-2)、白介素-6(IL-6)、C反应蛋白(CRP)水平的影响。方法选取2020年10月至2023年3月安徽中医药大学附属太和中医院诊治的104例先兆流产孕妇作为研究对象。采用简单随机分组法分为观察组(n=52)和对照组(n=52)。对照组采用黄体酮注射液,观察组采用寿胎丸加减联合黄体酮注射液。治疗后,比较两组的证候评分、疗效,比较两组治疗前后的性激素及血清IL-2、IL-6、CRP水平。结果治疗后,观察组和对照组下腹坠痛、阴道出血、双膝酸软中医证候评分均低于治疗前,且观察组低于对照组(P<0.05);治疗后,观察组总有效率高于对照组(P<0.05);治疗后,观察组和对照组孕酮(P)、雌二醇(E_(2))、β-人绒毛膜促性腺激素(β-hCG)水平均高于治疗前,且观察组高于对照组(P<0.05);治疗后,观察组和对照组血清IL-2、IL-6、CRP水平均低于治疗前,且观察组低于对照组(P<0.05)。结论早期肾虚型先兆流产孕妇采用寿胎丸加减联合黄体酮注射液治疗,可有效提高性激素水平,降低血清IL-2、IL-6、CRP水平,具有较好的治疗效果。Objective To explore the influences of modified Shoutai Pill combined with progesterone injection on curative effect,sex hormones,serum interleukin-2(IL-2),interleukin-6(IL-6)and C-reactive protein(CRP)levels in patients with early threatened abortion of kidney deficiency type.Methods A total of 104 pregnant women with threatened abortion admitted to Taihe Traditional Chinese Medicine Hospital Affiliated to Anhui University of Traditional Chinese Medicine were selected as study objects from October 2020 to March 2023.According to simple random grouping method,they were divided into observation group(n=52)and control group(n=52).The control group was treated with progesterone injection,while observation group was treated with modified Shoutai Pill combined with progesterone injection.After treatment,the syndrome score and curative effect of the two groups were compared.The sex hormones,serum IL-2,IL-6 and CRP levels before and after treatment were compared between the two groups.Results After treatment,scores of traditional Chinese medicine(TCM)syndromes of lower abdominal pain,vaginal bleeding,knees soreness in observation group and control group were all lower than before treatment,and observation group was lower than control group(P<0.05).After treatment,the effective rate of observation group was higher than that of control group(P<0.05).After treatment,levels of progesterone(P),estradiol(E_(2)),β-human chorionic gonadotropin(β-hCG)in observation group and control group were all higher than before treatment,and observation group was higher than control group(P<0.05).After treatment,levels of serum IL-2,IL-6 and CRP in observation group and control group were all lower than before treatment,and observation group was lower than control group(P<0.05).Conclusions Modified Shoutai Pill combined with progesterone injection can effectively increase sex hormone levels and decrease serum IL-2,IL-6 and CRP levels in pregnant women with early threatened abortion of kidney deficiency type,with good curative effect.

关 键 词：寿胎丸 黄体酮注射液 先兆流产 性激素 白介素-2 白介素-6 C反应蛋白 

分 类 号：R711[医药卫生—妇产科学]