1例Lemierre’s综合征患者的药物治疗分析与监护  

Drug therapy analysis and care on a patient with Lemierre’s syndrome

作　　者：刘宇思 黄凌峰 黄勤淼 曹伟灵[1] 张鹏 LIU Yusi;HUANG Lingfeng;HUANG Qinmiao;CAO Weiling;ZHANG Peng(Dept.of Pharmacy,Shenzhen Luohu District People’s Hospital,Guangdong Shenzhen 518000,China;Dept.of Respiratory Medicine,Shenzhen Luohu District People’s Hospital,Guangdong Shenzhen 518000,China)

机构地区：[1]深圳市罗湖区人民医院药学部,广东深圳518000 [2]深圳市罗湖区人民医院呼吸内科,广东深圳518000

出　　处：《中国药房》2024年第8期997-1000,共4页China Pharmacy

基　　金：国家自然科学基金项目(No.82102118)。

摘　　要：目的为Lemierre’s综合征的早期诊断、药物治疗及用药监护提供参考。方法医师根据患者病情及血宏基因组二代测序检测结果确诊患者为Lemierre’s综合征,临床药师参与了该患者的治疗全过程。治疗过程中,临床药师针对坏死梭杆菌感染,建议予哌拉西林钠他唑巴坦钠联合甲硝唑抗感染治疗;针对左侧颈内静脉炎并血栓形成,建议予依诺肝素钠注射液抗凝治疗。结果医师采纳临床药师建议,患者病情好转,准予带药出院。结论临床药师通过解读血宏基因组二代测序检测结果,同时结合患者病情,协助医师为该患者制定了个体化抗感染治疗及抗凝治疗方案,并进行用药监护,确保了患者用药的安全有效。OBJECTIVE To provide a reference for the early diagnosis,drug treatment and medication monitoring for patients with Lemierre’s syndrome.METHODS The doctors confirmed the diagnosis of the patient as having Lemierre’s syndrome based on the patient’s condition and the results of metagenomic next-generation sequencing(mNGS),and the clinical pharmacists participated in the treatment process of the patient.During the treatment process,the clinical pharmacists suggested using piperacillin sodium and tazobactam sodium combined with metronidazole for anti-infective treatment against Fusobacterium necrophorum infection;clinical pharmacists recommend anticoagulant treatment with Enoxaparin sodium injection for left internal jugular vein thrombophlebitis.RESULTS The doctors accepted the suggestion of the clinical pharmacists,and the patient’s condition improved after treatment and was allowed to be discharged with medication.CONCLUSIONS By interpreting the results of mNGS,combined with the patient’s condition,the clinical pharmacists assist doctors in formulating individualized anti-infective and anticoagulant plans for the patient and provide medication monitoring,ensuring the safety and effectiveness of the patient’s medication.

关 键 词：Lemierre’s综合征 mNGS 坏死梭杆菌 临床药师 药学监护 

分 类 号：R969.3[医药卫生—药理学]