Estimation of secondary nucleation kinetics of benzoic acid in batch crystallizer  

作　　者：Yan Zhao Weiyuan Zhang Jinbo Ouyang Guangyang Hou Vamsi Krishna Kamaraju Brian Glennon 

机构地区：[1]School of Chemical Engineering,Hebei Normal University of Science and Technology,Qinhuangdao,066004,China [2]Synthesis and Solid State Pharmaceutical Centre,School of Chemical and Bioprocess Engineering,University College Dublin,Dublin 4,Ireland [3]Jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices,East China University of Technology,Nanchang,330013,China [4]APC Ltd,Dublin 4,Ireland

出　　处：《Particuology》2024年第4期232-239,共8页颗粒学报（英文版）

基　　金：supported by National Natural Science Foundation of China (grant Nos.22108061,22178054,and 22068002);Natural Science Foundation of Hebei Province (grant No.B2022407009);Academic and Technical Leader Training Program for Major Disciplinessin Jiangxi Province (grant No.20212BCJ23001).

摘　　要：The nucleation and growth kinetics of benzoic acid were determined in a population balance model,describing the seeded batch antisolvent crystallization process.The process analytical technologies(PATs)were utilized to record the evolution of chord length distributions(CLDs)in solid phase together with the concentration decay in liquid phase,which provided essential experimental information for parameter estimation.The model was solved using standard method of moments based on the moments calculated from CLDs and solute concentration.A developed model,incorporating the nucleation and crystal growth as functions of both supersaturation and solvent composition,has been constructed by fitting the zeroth moment of particles and concentration trends.The determined kinetic parameters were consequently validated against a new experiment with a different flow rate,indicating that the developed model predicted crystallization process reasonably well.This work illustrates the strategy in construct a population balance model for further simulation,model-based optimization and control studies of benzoic acid in antisolvent crystallization.

关 键 词：Benzoic acid Antisolvent crystallization Population balance equation NUCLEATION Growth 

分 类 号：O313[理学—一般力学与力学基础]