Current status and challenges in the application of microbial PHA particles  

作　　者：Jiaxuan Liu Ziqi Zhou Haoru Li Xinyu Yang Zeyu Wang jian Xiao Dai-Xu Wei 

机构地区：[1]Key Laboratory of Resource Biology and Biotechnology in Western China,Ministry of Education,School of Medicine,Department of Life Sciences and Medicine,Northwest University,Xi'an,710069,China [2]School of Clinical Medicine,Qujing Medical College,Qujing,655000,China [3]School of Physics and Electronic Information,Shangrao Normal University,Shangrao,334001,China [4]Zigong Affiliated Hospital of Southwest Medical University,Zigong Psychiatric Research Center,Zigong Institute of Brain Science,Zigong,643002,China

出　　处：《Particuology》2024年第4期286-302,共17页颗粒学报（英文版）

基　　金：supported by Grants from Key Science and Technology Plan Projects in Zigong (grant No.2022ZCNKY07);National Natural Science Foundation of China (grant No.31900950);Jiangxi Provincial Natural Science Foundation (grant No.20212BAB214048).

摘　　要：Polyhydroxyalkanoates(PHAs)are diversiform biopolyesters with a similar structure and different side chain groups,synthesized by a variety of microorganism.Due to their excellent biodegradability and biocompatibility,PHAs have been used for many applications,including medical implants,antibacterial agents and bioengineering.Nano-architecture is an emerging area for the use of PHAs.This review summarizes the current status and challenges of PHAs-based particles on the micro-and nano-scale,including their production,degradation,biological safety,and surface functionalization.We also focus on the applications of PHA particles in drug delivery systems,environment protection,tissue engi-neering,vaccine engineering,food science,biotechnology and cosmetics.Finally,the future development trends of PHAs-based particles are prospected.

关 键 词：Polyhydroxyalkanoates(PHAs) PARTICLES Synthetic biology Tissue engineering 

分 类 号：Q93[生物学—微生物学]