胃肠道移植物抗宿主病营养支持的研究进展  

Research progress on nutritional support for gastrointestinal graft-versus-host disease

作　　者：于海燕 张雪亭 刘岩 路筝 孙笑天 Yu Haiyan;Zhang Xueting;Liu Yan;Lu Zheng;Sun Xiaotian(Digestive Endoscopy,Department of Gastroenterology,the Fifth Medical Center of Chinese PLA General Hospital,Beijing 100071,China;Digestive Endoscopy,Department of Hepatology,the Fifth Medical Center of Chinese PLA General Hospital,Beijing 100039,China;Department of Internal Medicine,Beijing South District of Chinese PLA General Hospital,Beijing 100071,China)

机构地区：[1]解放军总医院第五医学中心消化内科消化内镜中心,北京100071 [2]解放军总医院第五医学中心肝病学部消化内镜中心,北京100039 [3]解放军总医院京南医疗区综合内科,北京100071

出　　处：《中华临床营养杂志》2024年第1期50-56,共7页Chinese Journal of Clinical Nutrition

摘　　要：胃肠道移植物抗宿主病是造血干细胞移植术后最严重的并发症之一,可发生于各年龄段患者,临床表现有恶心、呕吐、腹痛、腹泻等,严重者可直接影响患者的临床预后和疗效。该文就胃肠道移植物抗宿主病营养支持及饮食管理策略的研究进展做一综述,主要从营养风险筛查及评估、营养支持方案制定、营养监测、营养教育、营养干预途径及时机等方面进行分析研究,形成阶梯化营养支持模式,减少胃肠道移植物抗宿主病患者营养不良的风险,对改善患者全身状况、缓解消化道症状和降低并发症发生风险等都具有十分重要的临床意义。Gastrointestinal graft versus host disease is one of the most severe complications after hematopoietic stem cell transplantation,which can occur in patients of any age groups.Its clinical manifestations include nausea,vomit,abdominal pain,diarrhea and the like.Severe gastrointestinal graft versus host disease could directly influence the patients'clinical prognosis and therapeutic efficacy of transplantation.Here we had a review of the research progress on nutritional support and diet management strategies for gastrointestinal graft versus host disease.It is of great clinical significance to form a step-wise nutritional support model to reduce the risk of malnutrition in patients with gastrointestinal graft versus host disease,which would contribute to improving patients'general condition,relieving digestive tract symptoms,and reducing the risk of complications.

关 键 词：胃肠道 移植物抗宿主反应 营养支持 

分 类 号：R459.3[医药卫生—治疗学] R57[医药卫生—临床医学]