基于前列腺特异抗原筛查初诊前列腺癌患者的临床特征  

Clinical characteristics of newly diagnosed prostate cancer patients based on prostate⁃specific antigen screening

作　　者：王小芹[1] 汪彬[2] 路孟鑫 WANG Xiaoqin;WANG Bin;LU Mengxin(Teaching Office,Zhongnan Hospital of Wuhan University,Wuhan 430071,Hubei,China;Dept.of Urology,Suizhou Central Hospital of Hubei Province,Suizhou 441300,Hubei,China;Dept.of Urology,Zhongnan Hospital of Wuhan University,Wuhan 430071,Hubei,China)

机构地区：[1]武汉大学中南医院教学办公室,湖北武汉430071 [2]湖北省随州市中心医院泌尿外科,湖北随州441300 [3]武汉大学中南医院泌尿外科,湖北武汉430071

出　　处：《武汉大学学报（医学版）》2024年第3期349-352,共4页Medical Journal of Wuhan University

基　　金：武汉大学中南医院优秀博士(后)项目(编号:ZNYB2019006)。

摘　　要：目的:探讨基于前列腺特异抗原(PSA)筛查初诊前列腺癌患者相比于其他初诊患者的临床特征。方法:回顾性分析了武汉大学中南医院2017年6月至2021年9月411例初诊前列腺癌患者的临床资料,依据是否因PSA异常无相关症状而就诊分为PSA筛查前列腺癌组(PSA筛查组)和其他前列腺癌组(有症状组),对比分析两组患者年龄、血清总PSA水平、前列腺体积大小以及PSA密度的临床基线资料,并分析两组患者肿瘤T分期、是否伴淋巴结转移、是否骨转移、国际泌尿病理学会(ISUP)分级之间差异。结果:因PSA检查异常而无相关临床表现的初诊前列腺癌患者相比于其他就诊患者,其PSA水平更低、前列腺体积更小、T分期更早、淋巴结及骨转移率更低、病理分级更低。结论:基于PSA检查的前列腺癌人群筛查可以提高前列腺癌早期诊断率。Objective:To explore the clinical characteristics of newly diagnosed prostate cancer patients based on prostate⁃specific antigen(PSA)screening compared with other newly diagnosed patients.Methods:We retrospectively analyzed and compared the clinical data of 411 newly diagnosed prostate cancer patients in Zhongnan Hospital of Wuhan University from June 2017 to September 2021.Ac⁃cording to whether the hospital visits were due to abnormal PSA without related symptoms,the pa⁃tients were divided into a PSA screening prostate cancer group(PSA screening group)and another prostate cancer group(symptomatic group).The clinical baseline data,including patient age,total se⁃rum PSA level,prostate volume,and PSA density,were compared betweenthe two stratified groups.The differences in tumor T stage,lymph node metastasis,bone metastasis,and International Society for Urological Pathology(ISUP)grades between the two groups were also compared.Results:Com⁃pared with other newly diagnosed prostate cancer patients,newly diagnosed prostate cancer patients with abnormal PSA without related symptoms had lower PSA levels,smaller prostate volume,earlier T stage,lower lymph node and bone metastasis rate,and lower pathological grade.Conclusion:Pros⁃tate cancer screening based on PSA tests can improve the early diagnosis rate of prostate cancer.

关 键 词：前列腺癌 前列腺特异抗原筛查 临床特征 早期诊断 

分 类 号：R737.25[医药卫生—肿瘤]