地舒单抗联合椎体成形术治疗胸腰椎压缩性骨折的疗效  

Effect of denosumab combined with vertebroplasty in patients with thoracic compression fractures

作　　者：石秀峰[1] 袁伶俐[1] 陈淑芳[1] 张先棠[1] 施华 欧如梦 张莉[1] SHI Xiufeng;YUAN Lingli;CHEN Shufang;ZHANG Xiantang;SHI Hua;OU Rumeng;ZHANG Li(Department of Orthopedics,Second Affiliated Hospital of Bengbu Medical College,Bengbu 233000,China)

机构地区：[1]蚌埠医学院第二附属医院骨科,233000

出　　处：《国际骨科学杂志》2024年第2期146-149,共4页International Journal of Orthopaedics

基　　金：安徽省蚌埠医学院自然科学重点项目(BYKY2019134ZD)。

摘　　要：目的探究地舒单抗联合椎体成形术治疗胸腰椎压缩性骨折的疗效。方法回顾性选择2022年1月至2024年1月60例行椎体成形术治疗的胸腰椎压缩性骨折患者为研究对象,按照术后抗骨质疏松方案不同将患者分为观察组和对照组,各30例,其中对照组采取常规钙剂治疗,观察组采取常规钙剂治疗联合地舒单抗干预。比较两组患者Oswsetry功能障碍指数(ODI)、日本骨科协会腰痛功能评定表(M-JOA)、疼痛视觉模拟评分(VAS),伤椎后凸角、伤椎前缘高度、骨密度,治疗有效率及治疗期间再骨折率。结果观察组治疗有效率显著高于对照组(P<0.05)。治疗后,两组患者VAS评分均较治疗前显著降低,观察组患者降低程度更大,两组差异有统计学意义(P<0.05);两组患者ODI评分均较治疗前显著降低,M-JOA评分均较治疗前显著升高,观察组患者改善情况显著优于对照组(P<0.05)。观察组伤椎前缘高度、伤椎后凸角、骨密度改善情况显著优于对照组(P<0.05)。观察组再骨折率显著低于对照组,两组差异具有统计学意义(P<0.05)。结论地舒单抗联合椎体成形术治疗胸腰椎压缩性骨折能有效提升治疗效果,改善腰椎功能,提高骨密度,减少二次骨折。Objective This study aimed to investigate the effect of denosumab combined with vertebroplasty in the treatment of thoracolumbar vertebral compression fractures.Methods Sixty patients with thoracolumbar compression fractures who underwent vertebroplasty in our hospital from January 2022 to January 2024 were retrospectively selected as the study subjects.They were divided into an observation group and a control group,with 30 cases in each group,according to the postoperative anti-osteoporosis program.The control group was treated with vertebroplasty combined with routine calcium,and the observation group was treated with denosumab,vertebroplasty,and calcium.Changes in the Oswsetry dysfunction index(ODI),Japanese Orthopedic Society Low Back Pain Function Rating Scale(M-JOA),visual analog pain rating scale(VAS),kyphotic angle,anterior vertebrae height,bone mineral density of the injured vertebrae,treatment effectiveness,and the rate of refracture during treatment were observed and compared between the two groups one month after continuous intervention.Results After rehabilitation treatment,certain clinical expectations were achieved,and the effective rate of the observation group was significantly higher than that of the control group(P<0.05).VAS scores were significantly reduced in both groups,and the reduction was greater in the observation group(P<0.05).ODI scores were significantly reduced,and M-JOA scores were increased in both groups(P<0.05).The improvement(increase or decrease)in the observation group was significantly better than in the control group(P<0.05).Improvements in the anterior height and kyphotic angle of the injured vertebrae in the observation group were significantly better than in the control group(P<0.05).The improved frontal height,kyphotic angle,and bone mineral density in the observation group were significantly better than in the control group.The refracture rate in the observation group was significantly lower than in the control group,and the difference was statistically significant(P<0.

关 键 词：地舒单抗 椎体成形术 胸腰椎压缩性骨折 

分 类 号：R687.3[医药卫生—骨科学]