Cryo-EM structure of cannabinoid receptor CB1-β-arrestincomplex  

作　　者：Yuxia Wang Lijie Wu Tian Wang Junlin Liu Fei Li Longquan Jiang Zhongbo Fan Yanan Yu Na Chen Qianqian Sun Qiwen Tan Tian Hua Zhi-Jie Liu 

机构地区：[1]iHuman Institute,ShanghaiTech University,Shanghai 201210,China [2]School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China [3]Institute of Molecular and Clinical Medicine,Kunming Medical University,Kunming 650500,China

出　　处：《Protein & Cell》2024年第3期230-234,共5页蛋白质与细胞（英文版）

基　　金：supported by the National Key Research and Development Program of China grant 2022YFA1302903(T.H.);the National Natural Science Foundation of China grant 91953202(Z.-J.L.);the CAS Strategic Priority Research Program XDB37030104(Z.-J.L.);the National Science Fund for Distinguished Young Scholars 32022038(T.H.);the National Natural Science Foundation of China grants 32230026(Z.-J.L.)and 32271262(T.H.);Shanghai Frontiers Science Center for Bomacromolecules and Precision Medicine.

摘　　要：Dear Editor,G protein-coupled receptors(GPCRs)play a vital role in regulating almost every aspect of human physiology,making up more than one-third of marketed drug targets(Santos et al.,2017).GPCRs orchestrate their signalling through interactions with three distinct downstream protein families:G proteins,G protein-coupled receptor kinases(GRKs),and arrestins(Santos et al.,2017).While G protein-mediated signalling is initiated upon GPCR stimulation,activated GPCRs return to their basal levels through a GRK-and arrestin-regulated desensitization process(Santos et al.,2017).In addition to modulating receptor desensitization,β-arrestin also regulates downstream events that are distinct from classical G protein signalling(Ahn et al.,2020).

关 键 词：STIMULATION RETURN 

分 类 号：Q51[生物学—生物化学]