烧伤患者血清ICAM-1、IL-10、TNF-α水平变化及与创面愈合程度的关系分析  

The changes of serum ICAM-1,IL-10 and TNF-αlevels in burn patients and their relationship with wound healing degree

作　　者：李茂清 贾鸿飞 高学坡 LI Maoqing;JIA Hongfei;GAO Xuepo(Department of Burn,Zhangjiakou First Hospital,Zhangjiakou 075000,China)

机构地区：[1]张家口市第一医院烧伤科,河北张家口075000

出　　处：《中国美容整形外科杂志》2024年第3期145-149,共5页Chinese Journal of Aesthetic and Plastic Surgery

基　　金：张家口市2022年市级科技计划项目(2221098D)。

摘　　要：目的分析烧伤患者血清细胞间黏附分子-1(intercellular adhesion molecule-1,ICAM-1)、白介素-10(interleukin-10,IL-10)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平变化及与创面愈合程度的关系。方法自2020年1月至2023年2月,张家口市第一医院烧伤科收治120例烧伤患者,对比患者入院后第1、28天的血清ICAM-1、IL-10、TNF-α水平;根据血清ICAM-1、IL-10、TNF-α水平的中位数,将患者分成高表达组与低表达组,并对比组间的创面愈合程度;采用Pearson相关分析烧伤患者的创面愈合程度与血清ICAM-1、IL-10、TNF-α的相关性;根据烧伤患者的创面愈合质量,采用ROC曲线评估血清ICAM-1、IL-10、TNF-α对烧伤患者创面愈合质量的预测价值。结果入院后第1、28天,烧伤患者的血清ICAM-1、IL-10、TNF-α水平相比,差异均有统计学意义(P<0.05)。ICAM-1高表达组的创面愈合程度明显低于ICAM-1低表达组(P<0.05);IL-10高表达组的创面愈合程度明显低于IL-10低表达组(P<0.05);TNF-α高表达组的创面愈合程度明显低于TNF-α低表达组(P<0.05)。Pearson相关性分析结果显示,烧伤患者的创面愈合程度与血清ICAM-1、IL-10、TNF-α均呈负相关(P<0.05)。ROC曲线结果显示,入院后第1天血清ICAM-1、IL-10、TNF-α的曲线下面积均大于入院后第28天,且三者联合检测的曲线下面积大于任一单一检测,表明三者联合检测可作为预测烧伤患者创面愈合质量的有效监测指标,且经过治疗后的血清ICAM-1、IL-10、TNF-α预测价值更高。结论血清ICAM-1、IL-10、TNF-α与烧伤患者的创面愈合程度呈负相关,三者联合检测能为临床预测创面愈合质量提供参考依据。Objective To analyze the changes of serum intercellular adhesion molecule-1(ICAM-1),interleukin-10(IL-10)and tumor necrosis factor-α(TNF-α)levels in burn patients and the relationship between them and the degree of wound healing.Methods A total of 120 burn patients admitted to Department of Burn,Zhangjiakou First Hospital,from January 2020 to February 2023 were selected,and the serum levels of ICAM-1,IL-10 and TNF-αat 1,28 days after admission were compared.According to the median levels of serum ICAM-1,IL-10 and TNF-α,the patients were divided into high expression group and low expression group,and the degree of wound healing between the groups was compared.Pearson correlation was used to analyze the correlation between the degree of wound healing and serum ICAM-1,IL-10 and TNF-αin burn patients.According to the wound healing quality of burn patients,the predictive value of serum ICAM-1,IL-10 and TNF-αon wound healing quality of burn patients was evaluated by ROC curve.Results On the 1,28 day after admission,the serum levels of ICAM-1,IL-10 and TNF-αin burn patients were significantly different(P<0.05).The wound healing degree of ICAM-1 high expression group was significantly lower than that of ICAM-1 low expression group(P<0.05).The wound healing degree of high IL-10 expression group was significantly lower than that of low IL-10 expression group(P<0.05).The wound healing degree of high TNF-αexpression group was significantly lower than that of low TNF-αexpression group(P<0.05).Pearson correlation analysis showed that the degree of wound healing in burn patients was negatively correlated with serum ICAM-1,IL-10 and TNF-α(P<0.05).ROC curve results showed that the area under the curve of serum ICAM-1,IL-10 and TNF-αon the 28 day after admission was greater than that of serum ICAM-1,IL-10 and TNF-αon the 1 day after admission,and the area under the curve of combined detection of the three was greater than that of any single detection.These results indicated that the combined detection of the three meth

关 键 词：烧伤 血清细胞间黏附分子-1 白介素-10 肿瘤坏死因子-α 创面愈合程度 

分 类 号：R644[医药卫生—外科学]