蛋白质琥珀酰化修饰的研究进展  

Research progress on protein modification by lysine succinylation

作　　者：刘怡 马海东 原夏萌 莫莎 程佳 朱振东 曾文先 LIU Yi;MA Haidong;YUAN Xiameng;MO Sha;CHENG Jia;ZHU Zhendong;ZENG Wenxian(School of Biological Science and Engineering,Shaanxi University of Technology,Hanzhong 723001,China;College of Animal Science and Technology,Qingdao Agricultural University,Qingdao 266109,China)

机构地区：[1]陕西理工大学生物科学与工程学院,陕西汉中723001 [2]青岛农业大学动物科技学院,山东青岛266109

出　　处：《黑龙江动物繁殖》2024年第2期24-30,共7页Heilongjiang journal of animal reproduction

基　　金：国家自然科学基金项目(32272884)。

摘　　要：蛋白质琥珀酰化修饰是通过酰化反应将琥珀酰基添加到蛋白质赖氨酸残基上。琥珀酰化修饰会影响蛋白质的结构和功能,进而调节信号传导和细胞代谢等生命活动。文章综述了蛋白质琥珀酰化修饰的位点分布、供体来源、琥珀酰基转移酶以及去琥珀酰化酶多个基本特征,并讨论了琥珀酰化修饰在能量代谢、细胞增殖、雄性生殖和自噬等生命活动中的重要作用,目的在于为进一步发现更多琥珀酰化修饰相关的酶与底物、了解其与琥珀酰化修饰相关的生物学功能提供参考。Protein succinylation in organisms is a process wherein a succinyl donor covalently binds a succinyl group to one or more protein lysine residues through enzymatic or non-enzymatic means,which leads to significant chemical and structural changes to the modified protein to regulate the metabolism and signal transduction in the cell.In this paper,the site distribution,donor source,succinyltransferase and desuccinylase of protein succinylation modification reviewed and the important role of succinylation in energy metabolism,cell proliferation,male reproduction and autophagy were discussed,aiming to provide a reference to discover more enzymes and substrates related to succinylation modification.

关 键 词：琥珀酰化修饰 转录 增殖 能量代谢 免疫 自噬 雄性生殖 

分 类 号：Q51[生物学—生物化学]