大剂量糖皮质激素冲击疗法对单侧全聋型突发性聋患者的临床疗效观察  

Clinical observation of high-dose glucocorticoid shock therapy on patients with unilateral total deafness with sudden sensorineural hearing loss

作　　者：刘佳荣 张莉[1] 段宏[1] Liu Jiarong;Zhang Li;Duan Hong(Department of Otorhinolaryngology,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学附属医院耳鼻咽喉头颈外科,呼和浩特010050

出　　处：《北京医学》2024年第2期103-106,共4页Beijing Medical Journal

摘　　要：目的 探讨大剂量糖皮质激素冲击疗法对单侧全聋型突发性聋(sudden sensorineural hearing loss, SSNHL)患者的临床疗效及安全性。方法 选取2020年8月至2022年8月内蒙古医科大学附属医院单侧全聋型SSNHL患者52例。随机分为治疗组和对照组,每组各26例。对照组采用糖皮质激素常规治疗,治疗组采用大剂量糖皮质激素冲击疗法,比较两组患者听力改善效果及不良反应情况。结果 52例患者中,男20例,女32例,年龄22~65岁,平均(45.4±11.3)岁。两组治疗后平均听阈值低于治疗前,且治疗组低于对照组;治疗组总有效率高于对照组(80.77%比53.85%),治疗期间治疗组不良反应发生率高于对照组(61.54%比19.23%),差异均有统计学意义(P<0.05)。结论 大剂量糖皮质激素冲击疗法能够有效改善单侧全聋型SSNHL患者听力,但治疗期间不良反应发生率较高。Objective To explore the clinical efficacy and safety of high-dose glucocorticoid shock therapy in patients with unilateral total deafness with sudden sensorineural hearing loss(SSNHL).Methods A total of 52 patients with unilateral total deafness with SSNHL in Affiliated Hospital of Inner Mongolia Medical University from August 2020 to August 2022 were were selected,and randomly divided into treatment group and control group,with 26 cases in each group.The control group was treated with routine glucocorticoid therapy,while the treatment group was treated with high-dose glucocorticoid shock therapy.The hearing improvement effect and adverse reactions of the two groups were compared.Results Among the 52 patients,there were 20 males and 32 females,aged from 22 to 65 years old,with an average of(45.4±11.3)years old.The average hearing threshold of the two groups after treatment was lower than that before treatment,and that of the treatment group was lower than that of the control group.The total effective rate in the treatment group was higher than that in the control group(80.77%vs.53.85%),and the incidence of adverse reactions in the treatment group was higher than that in the control group(61.54%vs.19.23%),and the differences were statistically significant(P<0.05).Conclusions The high-dose glucocorticoid shock therapy can effectively improve the hearing of patients with unilateral total deafness,but the incidence of adverse reactions during treatment is high.

关 键 词：突发性聋 单侧全聋型 糖皮质激素 大剂量 冲击疗法 临床疗效 

分 类 号：R764.437[医药卫生—耳鼻咽喉科]