八正散加减治疗慢性前列腺炎湿热瘀阻证  

Study on the therapeutic effect of modified Bazheng Powder in the treatment of chronic prostatitis with syndrome of stagnant dampness-heat

作　　者：王骏[1] 周峰[2] WANG Jun;ZHOU Feng(Department of Urology,Kunshan Hospital of Traditional Chinese Medicine,Suzhou 215006,China;Department of Urology,the First Affiliated Hospital of Suzhou University,Suzhou 215006,China)

机构地区：[1]昆山市中医医院泌尿外科,江苏苏州215006 [2]苏州大学附属第一医院泌尿外科,江苏苏州215006

出　　处：《长春中医药大学学报》2024年第4期429-432,共4页Journal of Changchun University of Chinese Medicine

基　　金：2020年姑苏卫生人才培养项目(GSWS2020021);2021年江苏省重点研发计划(社会发展)项目(BE2021651)。

摘　　要：目的探讨八正散加减治疗慢性前列腺炎湿热瘀阻证患者的临床疗效。方法选择80例基于表型分类系统(UPOINT)表型对症治疗的慢性前列腺炎湿热瘀阻证患者临床资料作为对照组,选择同期81例基于UPOINT表型对症治疗联合八正散加减治疗的慢性前列腺炎湿热瘀阻证患者临床资料作为观察组,患者均治疗6周。比较2组治疗前和治疗6周后排尿情况、心理状况、慢性前列腺炎症状积分指数(NIH-CPSI)评分、器官特异性症状、骨骼肌疼痛、感染症状。结果与治疗前比较,2组治疗6周后焦虑自评量表(SAS)、抑郁自评量表(SDS)、疼痛或不适、排尿症状、生活质量评分降低,观察组低于对照组(P<0.05),2组最大尿流率(MFR)、平均尿流率(AFR)升高,观察组高于对照组(P<0.05);2组局部触痛、腹部痉挛、骨盆部痉挛患者占比降低,观察组低于对照组(P<0.05)。结论八正散加减治疗慢性前列腺炎湿热瘀阻证型患者,可有效改善患者UPOINT表型,促进病情转归,具有较好的治疗效果。Objective To explore the clinical effect of modified Bazheng Powder in the treatment of chronic prostatitis with syndrome of stagnant dampness-heat.Methods Clinical data of 80 patients with chronic prostatitis with syndrome of stagnant dampness-heat received symptomatic treatment based on UPOINT phenotype classification system were selected as the control group,and clinical data of 81 patients with chronic prostatitis with syndrome of stagnant dampness-heat received symptomatic treatment combined with modified Bazheng Powder based on UPOINT phenotype classification system during the same period were selected as the observation group.All patients were treated for 6 weeks.The urination,psychological status,score of the National Institutes of Health chronic prostatitis symptom index(NIH-CPSI),organ-specific symptoms,skeletal muscle pain and infection symptoms between two groups before treatment and after 6 weeks of treatment were compared.Results Compared with before treatment,after 6 weeks of treatment,the scores of Self-rating Anxiety Scale(SAS)and Self-rating Depression Scale(SDS),and pain or discomfort,urination symptoms,and scores of quality of life in two groups decreased,and the observation group was lower than the control group(P<0.05).The maximum urine flow rate(MFR)and average urine flow rate(AFR)in two groups increased,and the observation group was higher than the control group(P<0.05).The proportion of patients with local tenderness,abdominal spasm,and pelvic spasm in two groups decreased,and the observation group was lower than the control group(P<0.05).Conclusion Modified Bazheng Powder can effectively improve the UPOINT phenotype of patients with chronic prostatitis with syndrome of stagnant dampness-heat,and promote the progression of the disease.This therapy has the good therapeutic effect.

关 键 词：慢性前列腺炎 湿热瘀阻证 表型分类系统 八正散 

分 类 号：R697.33[医药卫生—泌尿科学]