血清C反应蛋白、淀粉样蛋白A评估早期小儿肺炎支原体肺炎研究  

Study on the diagnosis of early childhood Mycoplasma pneumoniae pneumonia with serum C-reactive protein and serum amyloid protein A

作　　者：荣伟强 左路广 段娜娜 郝剑[1] 戚颖 RONG Weiqiang;ZUO Luguang;DUAN Nana;HAO Jian;QI Ying(Department of Blood Transfusion,the First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,China;Departmentof Laboratory,the First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,China;Department of Pharmacy,the First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,China)

机构地区：[1]河北北方学院附属第一医院输血科,河北张家口075000 [2]河北北方学院附属第一医院检验科,河北张家口075000 [3]河北北方学院附属第一医院药学部,河北张家口075000

出　　处：《长春中医药大学学报》2024年第4期455-458,共4页Journal of Changchun University of Chinese Medicine

基　　金：河北省卫生健康委科研基金项目(20211499)。

摘　　要：目的探究血清C反应蛋白(CRP)、淀粉样蛋白A(SAA)水平在诊断小儿肺炎支原体肺炎中的临床价值。方法选取2021年1月-2022年12月入院的肺炎支原体肺炎患儿60例为观察组,另选同期健康体检儿童60例为对照组。采集2组空腹静脉血,检测其CRP和SAA水平。比较2组CRP和SAA水平,对比单独血清CRP水平检测、血清SAA水平检测及2种方法联合检测对小儿肺炎支原体肺炎的诊断效能。结果观察组血清CRP和血清SAA水平高于对照组(P<0.05)。以病原体检测的结果为金标准,血清CRP检测检查显示小儿肺炎支原体肺炎阳性患者50例,阴性患者70例;血清SAA检测检查显示小儿肺炎支原体肺炎阳性患者55例,阴性患者65例;血清CRP和SAA联合检测显示小儿肺炎支原体肺炎阳性患者57例,阴性患者63例。单独血清CRP、单独血清SAA及联合检测诊断小儿肺炎支原体肺炎的敏感度分别为75.00%、86.67%、91.66%,特异度分别为91.67%、95.00%、96.67%,Kappa值分别为0.833、0.908、0.942。血清CRP和SAA联合检测诊断小儿肺炎支原体肺炎的敏感度和特异度较单独血清CRP、单独血清SAA检测高。ROC曲线结果显示,单独血清CRP诊断小儿肺炎支原体肺炎的AUC值为0.835(95%CI:0.718~0.880),截断值为11.55 mg·L^(-1),单独血清SAA诊断小儿肺炎支原体肺炎的AUC值为0.895(95%CI:0.832~0.958),截断值为30.45 mg·L^(-1),联合检测的AUC值为0.965(95%CI:0.933~0.998)(P<0.05)。结论CRP、SAA水平针对小儿肺炎支原体肺炎诊断的价值较高,联合检测的诊断效能更佳,敏感度和特异度均表现为较高水平,可为临床诊断小儿肺炎支原体肺炎提供参考。Objective To explore the clinical value of serum C-reactive protein(CRP)and serum amyloid A(SAA)levels in the diagnosis of Mycoplasma pneumoniae pneumonia in children.Methods Sixty children with Mycoplasma pneumoniae pneumonia admitted for treatment from January 2021 to December 2022 were selected as the observation group,and anothor 60 healthy children who underwent physical examinations during the same period were selected as the control group.Fasting venous blood was collected from two groups,and the CRP and SAA levels were measured.CRP and SAA levels of two groups were compared.And the diagnostic efficacy of serum CRP level detection alone,serum SAA level detection alone,and combined detection of two indicator levels for pediatric Mycoplasma pneumoniae pneumonia was compared.Results The levels of serum CRP and SAA in the observation group were higher than those in the control group(P<0.05).Using the results of pathogen detection as the gold standard,serum CRP level detection showed 50 positive patients and 70 negative patients with Mycoplasma pneumoniae pneumonia in children;The serum SAA level detection showed that there were 55 positive patients and 65 negative patients with Mycoplasma pneumoniae pneumonia in children;The combined detection of serum CRP level and SAA level showed 57 positive patients and 63 negative patients with Mycoplasma pneumoniae pneumonia in children.The sensitivity of serum CRP level alone,SAA level alone and combined detection level of both for diagnosing Mycoplasma pneumoniae pneumonia in children was75.00%,86.67% and 91.66%,respectively.The specificity was 91.67%,95.00%,and 96.67%,respectively.The Kappa values were 0.833,0.908,and 0.942,respectively.The sensitivity and specificity of the combined detection level of serum CRP and SAA in diagnosing Mycoplasma pneumoniae pneumonia in children were higher than those of the detection level of serum CRP alone and the detection level of serum SAA alone.The ROC curve results showed that the AUC value of serum CRP alone for diagnosing Myco

关 键 词：血清C反应蛋白 淀粉样蛋白A 肺炎支原体肺炎 感染标志物 诊断价值 

分 类 号：R725.6[医药卫生—儿科]