低温等离子下声门上成形术治疗婴幼儿喉软化症的效果  

Effect of Supraglottoplasty Under Low Temperature Plasma in the Treatment of Infantile Laryngomalacia

作　　者：乾恩乐[1] 姜岚[1] 任红波 王晓东[1] QIAN Enle;JIANG Lan;REN Hongbo;WANG Xiaodong(Department of Otorhinolaryngology Head and Neck Surgery,Children’s Hospital Affiliated to Zhengzhou University/Henan Children’s Hospital Zhengzhou Children’s Hospital,Zhengzhou 450018,China)

机构地区：[1]郑州大学附属儿童医院/河南省儿童医院郑州儿童医院耳鼻咽喉头颈外科,河南郑州450018

出　　处：《河南医学研究》2024年第7期1180-1183,共4页Henan Medical Research

基　　金：国家区域医疗中心开放课题资助项目(NRMC0105)。

摘　　要：目的探究接受低温等离子下声门上成形术治疗喉软化症患儿的临床效果及其对婴幼儿免疫功能的影响。方法选择郑州大学附属儿童医院2018年6月至2022年2月就诊的55例重度喉软化症患儿,出生时间为30~317 d,按照治疗方式分为等离子组和对照组,等离子组患儿接受低温等离子下声门上成形术治疗,对照组为家长拒绝手术要求保守治疗组,等离子组30例,对照组25例。观察和记录两组患儿的疗效,检测两组患儿血清IgG、IgM和补体C3、C4水平,并进行统计分析。结果术后1个月,等离子组患儿治愈22例,治愈率为73.3%,对照组治愈0例;术后3个月,等离子组患儿治愈30例,治愈率为100%,对照组治愈2例,治愈率为8%,未治愈的92%患儿3个月后又选择手术治疗。术后1个月和3个月两组的治愈率比较,等离子组高于对照组(P<0.01)。术后1个月等离子组血清IgG和补体C3、C4水平低于对照组(P<0.05)。结论低温等离子下声门上成形术治疗婴幼儿喉软化症疗效确切,且可改善患儿免疫功能紊乱状态。Objective To investigate the clinical effect of supraglottoplasty under low temperature plasma in infantile with laryngomalacia and its influence on infantile immune function.Methods A total of 55 infant with severe laryngomalacia in Children’s Hospital Affiliated to Zhengzhou University from June 2018 to February 2022 were selected,with a birth time of 30 to 317 days.They were divided into plasma group and control group according to the choice of treatment methods.Patients in plasma group received supraglottoplasty under low temperature plasma,while patients in control group refused surgery and request conservative treatment,30 in plasma group and 25 in control group.The postoperative curative effect of the two groups of infant were observed and recorded.The contents of serum IgG,IgM and complement C3 and C4 in both groups of infant were detected,and conducted statistical analysis.Results One month after surgery,22 infant in the plasma group were cured,the cure rate was 73.3%,while 0 in the control group.Three months after surgery,29 infant in the plasma group were cured,the cure rate was 96.7%.While 2 newborn in the control group were cured,the cure rate was 8%,the remaining 92%of infant chose surgical treatment three months later.The cure rate of the plasma group was higher than that of the control group at 1 and 3 months after surgery(P<0.01).One month after surgery,the contents of serum IgG and complement C3 and C4 in plasma group were lower than those in control group(P<0.05).Conclusion Supraglottoplasty under low temperature plasma is effective in the treatment of infantile laryngomalacia and can improve the immune dysfunction status of infant.

关 键 词：婴幼儿 喉软化症 免疫功能 低温等离子 声门上成形术 

分 类 号：R767[医药卫生—耳鼻咽喉科]