血清IL-8、ESM-1、VAP-1在慢性阻塞性肺疾病临床诊断及病情评估中的应用  

Application of Serum IL-8,ESM-1 and VAP-1 in Clinical Diagnosis and Disease Assessment of Chronic Obstructive Pulmonary Disease

作　　者：刘传[1] 于卫民[1] 王嵘 李丽娟 LIU Chuan;YU Weimin;WANG Rong;LI Lijuan(Department of Respiratory and Critical Care Medicine,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 451162,China;Department of Endocrinology,Kaifeng Hospital of Traditional Chinese Medicine,Kaifeng 475000,China)

机构地区：[1]郑州大学第一附属医院呼吸与危重症医学科,河南郑州451162 [2]开封市中医院内分泌科,河南开封475000

出　　处：《河南医学研究》2024年第7期1219-1223,共5页Henan Medical Research

摘　　要：目的探讨慢性阻塞性肺疾病(COPD)患者血清白细胞介素-8(IL-8)、内皮特异性分子-1(ESM-1)、血管黏附蛋白-1(VAP-1)表达水平,分析其与病情程度相关性及其对COPD的诊断价值。方法选取2021年11月至2022年8月郑州大学第一附属医院收治的153例COPD患者为研究对象,其中COPD稳定期42例(设为SCOPD组)、COPD急性加重期111例(设为AECOPD组),同时选取同期于医院体检的健康志愿者51例为对照组。比较两组临床资料及血清IL-8、ESM-1、VAP-1水平。对比不同病情程度患者血清IL-8、ESM-1、VAP-1水平。分析血清各指标与肺功能、生化指标、病情程度相关性。评价血清各指标对SCOPD、AECOPD的诊断价值。结果AECOPD组、SCOPD组血清IL-8、ESM-1、VAP-1水平高于对照组,且AECOPD组高于SCOPD组(P<0.05);IL-8、ESM-1、VAP-1与生化指标、COPD评估测试表(CAT)、病情程度呈正相关,与肺功能呈负相关(P<0.05);血清各指标联合诊断SCOPD与AECOPD的曲线下面积(AUC)大于单独指标诊断(P<0.05)。结论血清IL-8、ESM-1、VAP-1与COPD病情严重程度相关,联合检测其水平对COPD具有一定诊断价值,可能作为疾病诊断、病情评估的重要指标。Objective To investigate the expression levels of serum interleukin-8(IL-8),endothelial specific molecule-1(ESM-1)and vascular adhesion protein-1(VAP-1)in patients with chronic obstructive pulmonary disease(COPD),and to analyze their correlation with the degree of disease and their diagnostic value for COPD.Methods One hundred and fifty-three COPD patients admitted to the First Affiliated Hospital of Zhengzhou University from November 2021 to August 2022 were selected for the study,including 42 cases in the stable phase of COPD(set as SCOPD group)and 111 cases in the acute exacerbation phase of COPD(set as AECOPD group),while 51 healthy volunteers who were examined at the hospital during the same period were selected as the control group.The clinical data and serum IL-8,ESM-1 and VAP-1 levels of each group were compared.Serum IL-8,ESM-1,and VAP-1 levels were compared in patients with different degrees of disease.The correlation between serum indices and pulmonary function,biochemical indices,and the degree of disease were analyzed.The diagnostic value of serum indicators for SCOPD and AECOPD were evaluated.Results Serum IL-8,ESM-1,and VAP-1 levels were higher in the AECOPD and SCOPD groups than those in the control group,and higher in the AECOPD group than that in the SCOPD group(P<0.05).IL-8,ESM-1,and VAP-1 were positively correlated with biochemical indexes,COPD assessment test scale(CAT)and degree of disease,and negatively correlated with pulmonary function(P<0.05).The area under the curve(AUC)of the combined diagnosis of SCOPD and AECOPD with the serum indicators was greater than that of the individual indicators(P<0.05).Conclusion Serum IL-8,ESM-1 and VAP-1 are correlated with the severity of COPD,and their combined levels have some diagnostic value for COPD,and may be used as important indicators for disease diagnosis and disease assessment.

关 键 词：慢性阻塞性肺疾病 白细胞介素-8 内皮特异性分子-1 血管黏附蛋白-1 诊断价值 

分 类 号：R563.3[医药卫生—呼吸系统]