噻托溴铵联合大容量全肺灌洗术治疗尘肺病合并慢性阻塞性肺疾病患者的效果  

Effects of Tiotropium bromide combined with whole lung lavage in treatment of pneumoconiosis complicated with chronic obstructive pulmonary disease

作　　者：段德昌 宋英利 黄玉梅 陈优梅 崔开旺 DUAN Dechang;SONG Yingi;HUANG Yumei;CHEN Youmei;CUI Kaiwang(Occupational Health Department of Ganzhou Center for Disease Control and Prevention,Ganzhou 341000 Jiangxi,China;Department of Respiratory and Critical Care Medicine of the Fifth People’s Hospital of Ganzhou,Ganzhou 341000 Jiangxi,China)

机构地区：[1]赣州市疾病预防控制中心职业卫生科,江西赣州341000 [2]赣州市第五人民医院呼吸与危重症医学科,江西赣州341000

出　　处：《中国民康医学》2024年第7期38-40,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察噻托溴铵联合大容量全肺灌洗术治疗尘肺病合并慢性阻塞性肺疾病(COPD)患者的效果。方法:回顾性分析2020年1月至2023年3月赣州市第五人民医院收治的82例尘肺病合并COPD患者的临床资料,按照治疗方法不同将其分为对照组40例和观察组42例。两组均予以常规治疗,在此基础上,对照组采用大容量全肺灌洗术治疗,观察组在对照组基础上联合噻托溴铵治疗,比较两组临床疗效,治疗前后肺功能指标[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、呼气流量峰值(PEF)]水平、血气分析指标[动脉血二氧化碳分压(PaCO_(2))、动脉血氧分压(PaO_(2))、pH值]水平,以及不良反应发生率。结果:观察组治疗总有效率为97.62%(41/42),高于对照组的80.00%(32/40),差异有统计学意义(P<0.05);治疗后,观察组FEV1、FVC、PEF水平均高于对照组,差异有统计学意义(P<0.05);治疗后,观察组PaCO_(2)水平低于对照组,PaO_(2)、pH值均高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:噻托溴铵联合大容量全肺灌洗术治疗尘肺病合并COPD患者可提高治疗总有效率和肺功能指标水平,改善血气分析指标水平,效果优于单纯大容量全肺灌洗术治疗。Objective:To observe effects of Tiotropium bromide combined with whole lung lavage in treatment of pneumoconiosis complicated with chronic obstructive pulmonary disease(COPD).Methods:The clinical data of 82 patients with pneumoconiosis complicated with COPD admitted to the Fifth People’s Hospital of Ganzhou from January 2020 to March 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group(40 cases)and observation group(42 cases).Both groups were given routine treatment.On this basis,the control group was treated with whole lung lavage,while the observation group was treated with Tiotropium bromide on the basis of that of the control group.The clinical efficacy,the lung function indexes[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),peak expiratory flow(PEF)]levels,the blood gas analysis indexes[arterial partial pressure of carbon dioxide(PaCO_(2)),arterial partial pressure of oxygen(PaO_(2)),pH]levels,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the observation group was 97.62%(41/42),which was higher than 80.00%(32/40)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FEV1,FVC and PEF in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the level of PaCO_(2) in the observation group was lower than that in the control group,the levels of PaO_(2) and pH were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Tiotropium bromide combined with whole lung lavage can improve the total effective rate,the lung function index levels and the blood gas analysis index levels in the treatment of the pneumoconiosis patients wi

关 键 词：噻托溴铵 大容量全肺灌洗术 尘肺病 慢性阻塞性肺疾病 肺功能 血气分析 不良反应 

分 类 号：R563[医药卫生—呼吸系统]