病毒类基因工程疫苗研究进展  

Research Advances of Virus-Based Genetically Engineered Vaccines

作　　者：李洪珊 李殿玉 李向茸[1,2,4] 冯若飞[1,2,4] LI Hongshan;LI Dianyu;LI Xiangrong;FENG Ruofei(Key Laboratory of Biotechnology and Bioengineering of Stat e Ethnic Affairs Commission,Biomedical Research Center,Northwest Minzu University,Lanzhou 730030,China;Gansu Tech Innovation Center of Animal Cell,Biomedical Research Center,Lanzhou 730030,China;Life Science and Engineering College of Northwest Minzu University,Lanzhou 730030,China;Engineering Research Center of key technologies and industrialization of cell matrix vaccine,Ministry of Education,Northwest Min zu University,Lanzhou 730030,China)

机构地区：[1]西北民族大学、生物医学研究中心生物工程与技术国家民委重点实验室,甘肃兰州730030 [2]西北民族大学生物医学研究中心、甘肃省动物细胞技术创新中心,甘肃兰州730030 [3]西北民族大学生命科学与工程学院,甘肃兰州730030 [4]西北民族大学、生物医学研究中心细胞基质疫苗关键技术与产业化教育部工程研究中心,甘肃兰州730030

出　　处：《西北民族大学学报（自然科学版）》2024年第1期40-53,共14页Journal of Northwest Minzu University(Natural Science)

基　　金：国家自然科学基金项目(32260037);西北民族大学中央高校基本科研业务费资金项目(31920220068,31920210051);甘肃省高等学校青年博士基金项目(2021QB-064)。

摘　　要：疫苗接种被认为是控制病原体和预防人类以及动物疾病最有效的方法之一.近年来由于病毒性疾病来势汹汹,传统疫苗如灭活或减毒活疫苗的局限性及潜在问题日益突显,而基因工程技术的进步使得疫苗设计和研发得以改进,由此衍生的病毒类基因工程疫苗作为下一代疫苗越来越受到研究者的高度关注.通过病毒类基因工程疫苗的类型,重点介绍不同疫苗的开发原理、特点及用途,探讨其应用前景和发展趋势,旨在为新发病毒类疾病疫苗的研发提供参考.Vaccination is considered to be one of the most effective ways to control pathogens and prevent human and animal diseases.In recent years,with the frequent occurrence of viral diseases,the limitations and potential problems of traditional vaccines,such as inactivated or attenuated live vaccines,have become increasingly apparent.Advances in genetic engineering technology have improved vaccine design and development strategies,therefore,the derivation of virus-based genetically engineered vaccines has received extensive scientific and public attention.This review sorts out the types of virus-based genetically engineered vaccines and focus on the development principles,characteristics,and applications of different vaccines.This article aims to discuss the prospects for its application and development trends,and provide a reference for the development of vaccines for emerging viral-based diseases.

关 键 词：病原体 基因工程技术 亚单位疫苗 病毒载体疫苗 核酸疫苗 

分 类 号：S582.65[农业科学—作物学] R373[医药卫生—病原生物学]