针刺治疗轻度认知功能障碍的机制和临床研究进展  

The Mechanism and Clinical Research Progress of Acupuncture Treatment for Mild Cognitive Impairment

作　　者：佟欣[1] 秦鸿宇 曹丹娜[2] 冯楚文 李晓陵 TONG Xin;QIN Hongyu;CAO Danna;FENG Chuwen;LI Xiaoling(Heilongjiang University of Chinese Medicine,Harbin 150040,China;The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040

出　　处：《中医药信息》2024年第4期70-74,共5页Information on Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82074537,82074539);教育部“春晖计划”合作科研项目(HZKY20220308-202201357)。

摘　　要：轻度认知功能障碍(MCI)是正常老年化和老年期阿尔茨海默病之间的过渡阶段。据统计,10%~15%MCI患者会转变为AD,转化率是正常老龄化的10倍。针刺作为中医学的重要组成部分,疗效和安全性已经过国内大量临床验证,其具有多靶点、多途径和多层面的作用特点,安全、有效,在临床中广泛用于治疗MCI。笔者对针刺治疗MCI的机制和临床相关研究文献进行总结,发现针刺可以抑制Aβ沉积、Tau蛋白的过度磷酸化、炎症反应、氧化应激,调节胆碱能系统,发挥治疗作用;在临床治疗中,针药结合治疗MCI的疗效更好,具有良好的协同作用。Mild cognitive impairment(MCI)is a transitional stage between normal aging and age-related AD.According to statistics,10%to 15%of MCI patients will change to AD,and the conversion rate is 10 times that of normal aging.Acupuncture,as an important part of traditional Chinese medicine,has been widely used in the treatment of MCI because of its efficacy and safety,which has been verified by a large number of domestic clinical trials.It has the characteristics of multi-target,multi-pathway and multifaceted action,and is safe and effective.The author summarized the mechanism of acupuncture treatment of MCI and related clinical research literature,and found that acupuncture can inhibit Aβdeposition,Tau protein hyperphosphorylation,inflammatory response,oxidative stress,and regulate the cholinergic system.In clinical treatment,the combination of acupuncture and medicine in the treatment of MCI has a better effect and a good synergistic effect.

关 键 词：针刺 轻度认知功能障碍 综述 

分 类 号：R246.6[医药卫生—针灸推拿学]