强的松在过敏性紫癜患儿肾损害预防中的应用  

The application of prednisone in the prevention of renal damage in children with allergic purpura

作　　者：王四华 徐美莲[2] 陈霞 WANG Si-hua;XU Mei-lian;CHEN Xia(Jianou Municipal Hospital,Jianou,353100,Fujian;Fujian Provincial Hospital,Fuzhou,350000,Fujian)

机构地区：[1]建瓯市立医院,福建建瓯353100 [2]福建省立医院,福建福州350000

出　　处：《黔南民族医专学报》2024年第1期61-64,共4页Journal of Qiannan Medical College for Nationalities

摘　　要：目的:探讨在过敏性紫癜患儿临床肾损害预防中应用强的松的价值。方法:对本院临床收治的80例过敏性紫癜患儿作回顾性分析,患儿依据治疗方法不同分组;对照组患儿采用潘生丁治疗,观察组采用潘生丁联合强的松治疗;比较两组的治疗效果。结果:治疗后,观察组患儿紫癜性肾炎发生率低于对照组(P<0.05),紫癜消失时间、胃肠道和关节症状缓解时间、肾损害患儿24 h尿蛋白排泄量少于对照组(P<0.05),在紫癜反复发作及肾损害患儿平均肾受累时间上,两组无明显差异(P>0.05);观察组患儿各项生活质量评分高于对照组(P<0.05)。结论:在临床过敏性紫癜患儿肾损害预防中,强的松作用明显,可有效预防患儿肾损害发生,提高患儿生存质量。Objective:To explore the value of prednisone in the prevention of clinical renal damage in children with allergic purpura.Methods:A retrospective analysis was conducted on 80 children with allergic purpura admitted to our hospital,and the children were grouped according to different treatment methods.The control group of children was treated with persantine,while the observation group was treated with persantine combined with prednisone;the therapeutic effects of the two groups were compared.Results:After treatment,the incidence of purpuric nephritis in the observation group was lower than that in the control group(P<0.05),and the time for purpura to disappear,the time for gastrointestinal and joint symptoms to alleviate,and the 24-hour urinary protein excretion in children with renal damage were less than those in the control group(P<0.05).There was no significant difference between the two groups in terms of the average renal involvement time of children with recurrent purpura and renal damage(P>0.05);the quality of life scores of children in the observation group were higher than those in the control group(P<0.05).Conclusion:In the prevention of renal damage in children with clinical allergic purpura,prednisone has a significant effect and can effectively prevent the occurrence of renal damage in children and improve their quality of life.

关 键 词：过敏性紫癜 强的松 肾损害 预防 

分 类 号：R725.5[医药卫生—儿科]