致雏鹅痛风新型鹅星状病毒研究进展  

Research Progress on Novel Goose Astrovirus causing Gout in Goslings

作　　者：向勇 唐铮 李林林 徐志宏 孙敏华 XIANG Yong;TANG Zheng;LI Linlin;XU Zhihong;SUN Minhua(Institute of Animal Health,Guangdong Academy of Agricultural Sciences/Key Laboratory for prevention and control of Avian Influenza and Other Major Poultry Diseases,Ministry of Agriculture and Rural Affairs/Key Laboratory of Livestock Disease Prevention of Guangdong Province/Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of Guangdong Province,Ministry of Agriculture and Rural Affairs,Guangdong Guangzhou 510640;College of Veterinary Medicine,South China Agricultural University,Guangdong Guangzhou 510642)

机构地区：[1]广东省农业科学院动物卫生研究所/农业农村部禽流感等家禽重大疾病防控重点实验室/广东省畜禽疫病防治研究重点实验室/农业农村部兽用药物与诊断技术广东科学观测实验站,广东广州510640 [2]华南农业大学兽医学院,广东广州510642

出　　处：《广东畜牧兽医科技》2024年第2期1-7,共7页Guangdong Journal of Animal and Veterinary Science

基　　金：广东省科技计划项目(2021B1212030015,2021B1212050021);广东省现代农业产业技术体系创新团队(2023KJ137);广东省畜禽疫病防治研究重点实验室(2023B1212060040)。

摘　　要：鹅星状病毒(Gooseastrovirus,GAstV)是我国近年来新发现的一种星状病毒属成员,主要危害3周龄以下雏鹅。雏鹅感染后以内脏器官表面和关节腔中显著的尿酸盐沉积为特征;其感染率高达80%,死亡率可达50%;未死亡雏鹅则出现生长抑制和免疫水平降低等现象,更易受到其他病原的侵害。GAstV既够能通过粪口途径水平传播,也可垂直传播,同时还具备跨宿主传播的能力。目前该病毒致病机制的研究进展较为缓慢且尚无针对该病的商品化生物制品,使得在制定该病的科学防控措施时仍缺乏充分的理论依据和健全的药物配套,导致该疾病的防控形势依然严峻,给我国养鹅业造成了巨大的经济损失。该文围绕GAstV的病原学、流行情况、致病性、免疫应答及其致病机制等方面进行了简要综述,以期为GAstV的深入研究和防控措施的初步制定提供参考。Goose astrovirus(GAstV)is a newly member of the astrovirus genus discovered recently in China,which mainly affects goslings under 3 weeks of age.The infection rate is as high as 80%,and the mortality rate can be as high as 50%.The goslings infected with GAstV but survived showed growth inhibition and decreased immune level,and were more susceptible to other pathogens.GAstV could be transmitted vertically as well as horizontally by fecal-oral route,and also showed the characteristics of cross-host transmission.Up to now,due to the lack of commercialized vaccine and other biological products for this virus and the slow progress of the research on its pathogenic mechanism,the scientific formulation and effective implementation of prevention and control measures for this disease still lacks a sufficient theoretical basis and a sound veterinary system,resulting in the grim situation of this disease prevention and control,which has caused great economic losses to the goose industry in China.In this paper,a brief review of the etiology,epidemiology,pathogenicity,immune response and its pathogenic mechanism of GAstV was carried out,with a view to providing a reference for the in-depth study of GAstV and the preliminary development of preventive and control measures.

关 键 词：鹅星状病毒 病原学 流行病学 致病性 免疫应答 致病机制 

分 类 号：S852.657[农业科学—基础兽医学]