STING信号通路在不同宿主疾病中的研究进展  

Research Progress on the STING Signaling Pathway in Different Hosts Disease

作　　者：王焕硕 牛瑞辉 赵亮 罗胜军 温肖会 宋帅 贾春玲 周秀蓉 吕殿红 WANG Huanshuo;NIU Ruihui;ZHAO Liang;LUO Shengjun;WEN Xiaohui;SONG Shuai;JIA Chunling;ZHOU Xiurong;LV Dianhong(Institute of Animal Health,Guangdong Academy of Agricultural sciences,Key Laboratory of Livestock Disease Prevention of Guangdong Province,Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of Guangdong Province,Guangzhou Guangdong 510640;College of Animal Science,Tibet Agriculture&Animal Husbandry University,Linzhi Xizang 860000;Zhaoqing Branch of Lingnan Modem Agricultural Science and Technology Guangdong Laboratory,Zhaoqing Guangdong 526238)

机构地区：[1]广东省农业科学院动物卫生研究所/广东省畜禽疫病防治研究重点实验室/农业农村部兽用药物与诊断技术广东科学观测实验站,广东广州510640 [2]西藏农牧学院动物科学学院,西藏林芝860000 [3]岭南现代农业科学与技术广东省实验室肇庆分中心,广东肇庆526238

出　　处：《广东畜牧兽医科技》2024年第2期57-64,84,共9页Guangdong Journal of Animal and Veterinary Science

基　　金：科技创新战略专项资金(高水平农科院建设)(202110TD和R2020PY⁃JC001);广东省动物疫病野外科学观测研究站项目(2021B1212050021);广东省农业科学院“十四五”学科团队资助项目(202122TD)。

摘　　要：cGAS-STING是一种细胞内DNA感受器,可以针对入侵的病原体和自身免疫性疾病激活先天性免疫应答,STING通路激活可启动干扰素调节因子(IRF3)和核因子(NF-κB)。IRF3能向细胞核内转运,并触发免疫刺激基因(ISGs)和Ⅰ型干扰素(IFNs)的表达,导致免疫细胞激活并迁移到靶细胞,NF-κB能驱动炎症细胞因子的产生。cGAS-STING可导致介导炎症反应的蛋白产生,并且能在宿主抵抗入侵的病原、自身免疫性疾病、肿瘤免疫和衰老相关炎症中发挥着独特和关键的作用。该文以cGAS-STING信号通路的结构和功能作为切入点,对其在不同宿主中的调控作用进行综合论述,以期为cGAS-STING的相关研究提供理论依据和参考价值。cGAS-STING is an intracellular DNA sensor that activates innate immune responses against invading pathogens and autoimmune diseases.Activation of the STING pathway initiates interferon regulatoryfactor IRF3 and NF-κB.IRF3 can be transported into the nucleus and trigger the expression of ISGs and type I IFNs,leading to the activation of immune cells and migration to target cells.NF-κB can drive the production of inflammatory cytokines.cGAS-STING can lead to the production of proteins that mediate inflammatory responses and plays a unique and critical role in host anti-pathogen,autoimmune diseases,tumor immunity and aging-related inflammation.In this paper,the structure and function of cGAS-STING signaling pathway are taken as the starting point,and its regulatory role in different hosts is comprehensively discussed,in order to provide theoretical basis and reference value for the related research of cGAS-STING.

关 键 词：STING 信号通路 先天性免疫 宿主疾病 

分 类 号：S852.4[农业科学—基础兽医学]