尿游离DNA的液体活检有望成为泌尿系疾病诊治的重要方向  

Liquid biopsy using urinary cell-free DNA is significant in the detection and treatment of urologic diseases

作　　者：刘雨婷 李伟霞 谢梦晨 郭洋洋 王昕 LIU Yuting;LI Weixia;XIE Mengchen;GUO Yangyang;WANG Xin(Department of Endocrinology,Jiangsu Province Hospital of Chinese Medicine,Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029;The First Clinical Medical College,NanjingUniversity of Chinese Medicine,Nanjing 210029,China)

机构地区：[1]南京中医药大学附属医院江苏省中医院内分泌科,江苏南京210029 [2]南京中医药大学第一临床医学院,江苏南京210029

出　　处：《现代泌尿外科杂志》2024年第4期379-382,共4页Journal of Modern Urology

摘　　要：尿液由泌尿系统直接产生,其中的游离DNA(cfDNA)携带了来源于泌尿系的基因组DNA,并且尿液样本具有非侵入性、数量不受限及获取方便等优点,因此尿cfDNA是诊治泌尿系疾病的一种很有潜力的生物标志物,对尿cfDNA进行液体活检在泌尿系疾病的诊治中具有重要的临床应用价值。本文就尿cfDNA在泌尿系疾病临床诊治中的应用研究作一综述。Urine is produced from the urinary system,and urinary cell-free DNA(cfDNA)carries genomic DNA directly secreted from urinary system.Urine samples are non-invasive,unlimited in quantity and easy to obtain,making urinary cfDNA a promising biomarker for urologic diseases.This article reviews the progress of clinical application of urinary cfDNA in urologic diseases.

关 键 词：尿液 游离DNA 泌尿系疾病 生物标志物 液体活检 

分 类 号：R69[医药卫生—泌尿科学]