用于颅颌面骨缺损修复的骨组织工程支架研究进展  

Progress of bone tissue engineering scaffolds for craniomaxillofacial bone defect repair

作　　者：朱俊霖 张晓南[1] ZHU Jun-lin;ZHANG Xiao-nan(Stemmatological Hospital of Chongqing Medical University,Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences,Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education,Chongqing City,401147,China)

机构地区：[1]重庆医科大学附属口腔医院,口腔疾病与生物医学重庆市重点实验室,重庆市高校市级口腔生物医学工程重点实验室,重庆401147

出　　处：《中国医疗美容》2024年第3期109-114,共6页China Medical Cosmetology

摘　　要：颌面部骨骼是具有咀嚼运动、机械承重和支持软组织以维持面部美观等多功能的器官,颌骨缺损会导致面部畸形和颌骨功能的丧失,严重影响患者的生活质量。超过临界尺寸的骨组织无法自行修复与再生,往往需要通过骨移植材料的植入来恢复功能。考虑到自体移植和同种异体移植技术的缺点(如发病率高、失败率高和宿主排斥),骨组织工程已被广泛应用为治疗骨缺损的一种策略。有机高分子聚合物与钛合金由于其生物相容性佳在骨组织工程中被使用较多,不同材料表面改性方法被应用在骨组织工程支架上以改进其生物学相容性以及实现功能化。此外,不同的骨组织工程支架制造方式对支架性能存在巨大影响,尤其体现在精确度,经济性,制造速度方面。因此,本文旨在综述应用于颌面部骨缺损修复的骨组织工程支架的研究进展,尤其集中于材料分类以及制造方法方面,并探讨和展望其发展方向。The maxillofacial skeleton is a multifunctional organ with functions such as masticatory movement,mechanical weight bearing,and support of soft tissues to maintain facial aesthetics.Jaw bone defects lead to facial deformity and loss of jaw function,which seriously affects the patient's quality of life.Bone tissue exceeding the critical size cannot repair and regenerate on its own and often requires the implantation of bone graft material to restore function.Considering the drawbacks of autograft and allograft techniques(e.g-,high morbidity,high failure rate,and host rejection),bone tissue engineering(BTE)has been widely used as a strategy to treat bone defects.Organic polymers and titanium alloys have been more frequently used in BTE due to their excellent biocompatibility,and different material surface modification methods have been applied to BTE scaffolds to improve their biocompatibility as well as to achieve functionalization.In addition,different manufacturing methods for bone tissue engineering scaffolds have a great impact on the performance of scaffolds,especially in terms of accuracy,economy,and manufacturing speed.Therefore,this paper aims to review the research progress of bone tissue engineering scaffolds for maxillofacial bone defect repair,especially focusing on the classification of materials and fabrication methods,and to discuss and prospect the development direction of these scaffolds.

关 键 词：骨组织工程 颅颌面骨缺损 生物材料 增材制造 静电纺丝 

分 类 号：R318.08[医药卫生—生物医学工程]