离子掺杂介孔生物活性玻璃的合成及应用研究  

Synthesis and Application of Ion-Doped Mesoporous Bioactive Glasses

作　　者：李其伟 廖建国[1] Qiwei Li;Jianguo Liao(School of Materials Science and Engineering,Henan Polytechnic University,Jiaozuo 454000,China)

机构地区：[1]河南理工大学材料科学与工程学院,焦作454000

出　　处：《化学进展》2024年第2期271-284,共14页Progress in Chemistry

基　　金：河南省科技攻关项目(No.222102310112,222102320028)资助。

摘　　要：骨填充和骨替代生物材料的研究与开发是骨修复领域重要的研究方向之一。介孔生物活性玻璃(MBG)因其具有良好的生物活性以及可调节的孔径和有序的介孔结构,将在骨修复再生中发挥重要作用。通过不同的制备加工方法能得到纤维、支架、中空结构或纳米颗粒结构的MBG;大量研究表明,在MBG中掺杂少量的治疗性无机离子,能赋予它们更多的生物学特性,包括成骨、抗菌、抗炎、止血或抗癌特性;而且无机离子掺杂的MBG作为支架或纳米颗粒加工后,仍然具有出色的生物活性反应。此外,通过在介孔结构内负载生物活性分子、治疗药物和干细胞可进一步改善MBG的性能。本文介绍了近年来MBG的合成、金属离子掺杂MBG的抗菌性能以及MBG在其他方面的应用进展。The research and development of bone filling and bone substitute biomaterials is one of the important research directions in the field of bone repair.Mesoporous bioactive glass(MBG)will play an important role in bone repair and regeneration because of its good bioactivity,adjustable pore size and ordered mesoporous structure.MBG with fiber,scaffold,hollow structure or nano-particle structure can be obtained by different preparation and processing methods.Many studies have shown that the incorporation of a small amount of therapeutic inorganic ions into MBG can endow them with more biological properties,including osteogenic,antibacterial,anti-inflammatory,hemostatic or anti-cancer properties.Moreover,MBG doped with inorganic ions still has excellent bioactivity after being processed as scaffolds or nanoparticles.In addition,the performance of MBG can be further improved by loading bioactive molecules,therapeutic drugs and stem cells into the mesoporous structure.In this paper,the synthesis of MBG,the antibacterial properties of metal ion-doped MBG and the application of MBG in other fields are reviewed.

关 键 词：介孔生物活性玻璃 骨再生 治疗性无机离子 生物性能 

分 类 号：TB321[一般工业技术—材料科学与工程] TQ129[化学工程—无机化工] TB32