中老年男性糖尿病患者25-羟维生素D与下肢感染病变研究  

Study on 25-hydroxyvitamin D and lower extremity infection lesions in middle-aged and elderly male patients with diabetes

作　　者：陶文玉 杨海英[1] 王飞英 冯倩 徐凡 李奕平[1] TAO Wenyu;YANG Haiying;WANG Feiying;FENG Qian;XU Fan;LI Yiping(Department of Endocrinology,Affiliated Hospital of Yunnan University,Kunming Yunnan 650021,China;Department of Clinical Laboratory,Affiliated Hospital of Yunnan University,Kunming Yunnan 650021,China)

机构地区：[1]云南大学附属医院内分泌科,云南昆明650021 [2]云南大学附属医院检验科,云南昆明650021

出　　处：《云南医药》2024年第2期15-20,共6页Medicine and Pharmacy of Yunnan

摘　　要：目的探讨中老年男性T2DM患者血清25-(OH)D与下肢感染病变的关系。方法中老年男性T2DM患者281例:未合并下肢感染(B组)184例,合并下肢感染(C组)97例;非糖尿病(A组)139例。分析血清25-(OH)D及检查指标相关性。结果25-(OH)D,C组低于B、A组,B组低于A组,差异有统计学意义(P<0.001)。总人群及T2DM患者25-(OH)D均与HbA1c负相关,与血钙(Ca)正相关。总人群中,25-(OH)D与WBC、NEU、NLR负相关,与HDL正相关(P<0.05)。T2DM患者25-(OH)D与病程、HbA1c、UACR、CRP、VPT均呈负相关,与BMI、血Ca、LYM、股深动脉中内膜厚度均正相关(P<0.05)。结论中老年男性T2DM合并下肢感染病变VitD缺乏明显,临床需关注25-(OH)D水平,以更好地防治糖尿病下肢感染病变进展。Objective To discuss the relationship between serum 25-(OH)D and lower extremity infectious lesions in middle-aged and elderly male patients with T2DM.Methods A total of 281 T2DM male patients were enrolled,including 184 patients without lower extremity infection in group B and 97 patients with lower extremity infection in group C.Non-diabetic group A included 139 people.Results 25-(OH)D in group C was significantly lower than that in groups B and A,and group B was lower than that in group A,there was statistical significance in the difference(P<0.05).25-(OH)D was negatively correlated with HbA1c and positively correlated with serum calcium(Ca)in the general population and in the diabetic patients.In the general population 25-(OH)D was negatively correlated with UACR in the diabetic patients.In the total population,there was the negative correlation between 25-(OH)D andWBC,neutrophil granulocyte,neutrophil to WBC,NEU and NLR,and positively correlated with HDL(P<0.05).In the T2DM patients,25-(OH)D was negatively correlated with the duration of diabetes,HbA1c,UACR,CRP,VPT,and positively correlated with BMI,serum Ca,LYM,and ultrasound intima thickness of deep femoral artery.Conclusions VitD is obviously deficient in the middle-aged and elderly T2DM males combined with lower limb infection.Physicians should pay attention to the level of 25-(OH)D to better prevent the progression of diabetic lower extremity infection.

关 键 词：25-羟维生素D 中老年男性 2型糖尿病 下肢感染病变 

分 类 号：R587.2[医药卫生—内分泌] R543.5[医药卫生—内科学]