基于数据挖掘分析含天花粉成方制剂的组方规律  

The Prescription Rule of Prescription Preparation Containing Radix Trichosanthis Based on Data mining

作　　者：陈燕红 张继州 蒋畅 雷婷 韩静 CHEN Yan-hong;ZHANG Ji-zhou;JIANG Chang;LEI Ting;HAN Jing(College of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,Fujian,China;Fujian Academy of Chinese Medical Science,Fuzhou 350003,Fujian,China)

机构地区：[1]福建中医药大学药学院,福建福州350122 [2]福建省中医药科学院,福建福州350003

出　　处：《医学信息》2024年第8期10-16,共7页Journal of Medical Information

基　　金：福建省自然科学基金项目(编号:2022J01861)。

摘　　要：目的基于中医传承计算平台(TCMICS)分析《中华人民共和国卫生部药品标准中药成方制剂》(简称《中药成方制剂》)含天花粉方剂组方规律,为临床应用及新药研发提供参考。方法运用中医传承计算平台(V3.0)软件,收集《中药成方制剂》中含天花粉方剂,整理后采用频次统计、关联规则等数据挖掘方法,对主治疾病、常用药对及组方规律进行分析,并对高频疾病和高频药对进行分析。结果共获得含天花粉方剂143首,涉及中药352味,主治疾病80种。其中,与天花粉合用药物多为清热解毒、化痰止咳平喘药如甘草、桔梗、黄芩、玄参等。高频主治疾病为咳嗽、感冒、喉痹、消渴等,且用于治疗的高频药物组合与疾病的临床治则基本一致。结论《中药成方制剂》中含天花粉方剂多具有清热生津、化痰止咳之功效。Objective To analyze the prescription rules of formulae containing Radix Trichosanthis in Pharmaceutical Standard of the Ministry of Health of People’s Republic of China-Preparation of Traditional Chinese Medicine Prescription(Hereinafter referred to as Preparation of Traditional Chinese Medicine Prescription)based on Traditional Chinese Medicine Inheritance Computing System(TCMICS),then provide reference for clinical application and researching and inventing in new Chinese medicine.Methods Through TCMICS(V3.0),formulae containing Radix Trichosanthis in Preparation of Traditional Chinese Medicine Prescription were collected and organized.Data mining methods,such as frequency statistics,association rules and others,were used to analyze attending diseases,compatibility with commonly used drugs and combination rules,and to conduct in-depth analysis of high-frequency diseases and medicine pairs.Results There were a total of 143 prescriptions containing Radix Trichosanthis,involving 352 kinds of traditional Chinese medicine and 80 attending diseases.Among them,most of the drugs used in combination with Radix Trichosanthis were heat-clearing and detoxifying,phlegm-eliminating and cough-alleviating drugs such as licorice,Platycodon grandiflorum,Radix Scutellariae,Radix Scrophulariae.The high frequency attending diseases were cough,influenza,pharyngitis,diabetes,and the combination of high-frequency drugs used for treatment was basically consistent with the clinical rule of the disease.Conclusion The formulae containing Radix Trichosanthis in Preparation of Traditional Chinese Medicine Prescription have the effect of clearing heat,promoting fluid,dissolving phlegm and relieving cough.

关 键 词：天花粉 中药成方制剂 中医传承计算平台 组方规律 

分 类 号：R285[医药卫生—中药学]