错配修复蛋白表达缺失与结直肠癌病理特征及预后的关系  

Relationship Between the Loss of Mismatch Repair Protein Expression and the Pathological Feature and Prognosis of Colorectal Cancer

作　　者：李东松 陈娉珊 蔡泰楠 蔡泽华 丁玉芝 童昊 LI Dong-song;CHEN Ping-shan;CAI Tai-nan;CAI Ze-hua;DING Yu-zhi;TONG Hao(Department of Hepatobiliary Surgery,People's Hospital of Chaozhou City,Chaozhou 521011,Guangdong,China;Department of Pathology,People's Hospital of Chaozhou City,Chaozhou 521011,Guangdong,China;Department of Gastrointestinal Surgery,People's Hospital of Chaozhou City,Chaozhou 521011,Guangdong,China)

机构地区：[1]潮州市人民医院肝胆外科,广东潮州521011 [2]潮州市人民医院病理科,广东潮州521011 [3]潮州市人民医院胃肠外科,广东潮州521011

出　　处：《医学信息》2024年第8期99-103,共5页Journal of Medical Information

基　　金：潮州市科技计划项目(编号:2021ZC15)。

摘　　要：目的探讨错配修复蛋白的表达状态与结直肠癌病理特征和预后的关系。方法纳入于2016年9月-2022年9月在潮州市人民医院诊治的190例临床及病理资料完整的结直肠癌患者进行分析。通过免疫组化方法检测病理标本中MLH1、MSH2、MSH6和PMS2的表达状态,其中有一个表达缺失则为dMMR组,全部均有表达则分为pMMR组。分析两组患者病理特征及预后情况。结果错配修复蛋白总缺失率为21.58%。两组患者的肿瘤大小、部位、淋巴结转移、肿瘤病理分期与错配修复蛋白表达状态具有相关性(P<0.05),而肿瘤组织学类型、肿瘤分化程度、神经和/或脉管侵犯与错配修复蛋白表达状态不具相关性(P>0.05)。Kaplan-Meier分析显示,dMMR组患者无病生存时间和总生存时间均优于pMMR组患者,差异有统计学意义(P<0.05)。结论错配修复蛋白表达状态与结直肠癌的肿瘤大小、部位、淋巴结转移、肿瘤病理分期有密切关系,同时错配修复蛋白缺失患者的无病生存时间和总生存时间也较长,提示预后较好。Objective To investigate the relationship between the expression of mismatch repair protein and the pathological characteristics and prognosis of colorectal cancer.Methods A total of 190 patients with colorectal cancer with complete clinical and pathological data who were treated in People’s Hospital of Chaozhou City from September 2016 to September 2022 were included in the analysis.The expression of MLH1,MSH2,MSH6 and PMS2 in pathological specimens was detected by immunohistochemistry.One of the expression deletions was dMMR group,and all of them were divided into pMMR group.The pathological characteristics and prognosis of the two groups were analyzed.Results The total deletion rate of mismatch repair protein was 21.58%.The tumor size,location,lymph node metastasis,tumor pathological stage of the two groups were correlated with the expression of mismatch repair protein(P<0.05),while there was no correlation between the expression of mismatch repair protein and the histological type of tumor,the degree of tumor differentiation,nerve and/or vascular invasion(P>0.05).Kaplan-Meier analysis showed that the disease-free survival time and overall survival time of patients in the dMMR group were better than those in the pMMR group,and the difference was statistically significant(P<0.05).Conclusion The expression of mismatch repair protein is closely related to the tumor size,location,lymph node metastasis and pathological stage of colorectal cancer.At the same time,the disease-free survival time and total survival time of patients with mismatch repair protein deletion are also longer,suggesting a better prognosis.

关 键 词：错配修复蛋白 结直肠癌 病理特征 预后 

分 类 号：R656.9[医药卫生—外科学]