联合纤维蛋白原、D二聚体与铁蛋白检测在小儿上呼吸道感染疾病诊断中的价值  

Value of Combined Detection of Fibrinogen,D-dimer and Ferritin in the Diagnosis of Upper Respiratory Tract Infection in Children

作　　者：吴建军 姜晓宇 王慧 WU Jian-jun;JIANG Xiao-yu;WANG Hui(Clinical Laboratory of Huangshi Municipal Maternal and Child Health Care Hospital,Huangshi 435000,Hubei,China;Operating Room of Huangshi Aier Eye Hospital,Huangshi 435000,Hubei,China)

机构地区：[1]黄石妇幼保健院检验科,湖北黄石435000 [2]黄石爱尔眼科医院手术室,湖北黄石435000

出　　处：《医学信息》2024年第8期125-128,共4页Journal of Medical Information

摘　　要：目的探讨纤维蛋白原(FIB)、D二聚体(D-D)及血清铁蛋白(FER)在小儿上呼吸道感染疾病中的诊断价值。方法收集2022年12月-2023年2月于黄石妇幼保健院确诊的96例小儿上呼吸道感染儿童作为观察组,根据病原学诊断结果分为病毒感染组(n=55)和细菌感染组(n=41);另选取同期于我院进行常规体检且结果正常的96名儿童作为对照组。比较各组FIB、D-D、FER水平差异,并采用Logistic多元回归模型分析小儿上呼吸道感染的影响因素,采用ROC曲线分析FIB、D-D、FER联合检测诊断小儿上呼吸道感染的价值。结果观察组FIB、D-D、FER水平高于对照组(P<0.05),且细菌感染组FIB、D-D、FER水平高于病毒感染组(P<0.05);Logistic多元回归模型分析显示,FIB、D-D、FER水平均为小儿上呼吸道感染的独立危险因素(P<0.0);ROC曲线分析显示,FIB、D-D、FER联合检测其ROC曲线下面积为0.966(95%CI:0.944~0.989),灵敏度与特异度分别为89.65%与96.93%,高于三者单独检测。结论常规联合检测FIB、D-D、FER水平有助于为临床诊断小儿上呼吸道感染提供一定的参考依据。Objective To investigate the diagnostic value of fibrinogen(FIB),D-dimer(D-D)and serum ferritin(FER)in children with upper respiratory tract infection.Methods A total of 96 children with upper respiratory tract infection diagnosed in Huangshi Municipal Maternal and Child Health Care Hospital from December 2022 to February 2023 were collected as observation group.According to the results of etiological diagnosis,they were divided into viral infection group(n=55)and bacterial infection group(n=41).In addition,96 children with normal results who underwent routine physical examination in our hospital during the same period were selected as the control group.The differences of FIB,D-D and FER levels in each group were compared.Logistic multiple regression model was used to analyze the influencing factors of upper respiratory tract infection in children.ROC curve was used to analyze the value of combined detection of FIB,D-D and FER in the diagnosis of upper respiratory tract infection in children.Results The levels of FIB,D-D and FER in the observation group were higher than those in the control group(P<0.05),and the levels of FIB,D-D and FER in the bacterial infection group were higher than those in the viral infection group(P<0.05).Logistic multiple regression model analysis showed that FIB,D-D and FER levels were independent risk factors for upper respiratory tract infection in children(P<0.05).ROC curve analysis showed that the area under the ROC curve of FIB,D-D and FER combined detection was 0.966(95%CI:0.944-0.989),and the sensitivity and specificity were 89.65% and 96.93%,respectively,which were higher than those of the three alone.Conclusion Routine combined detection of FIB,D-D and FER levels is helpful to provide some reference for clinical diagnosis of upper respiratory tract infection in children.

关 键 词：呼吸道感染 纤维蛋白原 D二聚体 铁蛋白 

分 类 号：R446[医药卫生—诊断学]