养血生发汤联合复方倍他米松注射液治疗斑秃患者的临床疗效观察  

Observation on clinical effect of Yangxue Shengfa decoction combined with compound betamethasone injection in the treatment of patients with alopecia areata

作　　者：周潇 ZHOU Xiao(Dermatological Department,Zibo Traditional Chinese Medicine Hospital,Zibo 255300,China)

机构地区：[1]淄博市中医医院皮肤科,255300

出　　处：《中国现代药物应用》2024年第7期24-28,共5页Chinese Journal of Modern Drug Application

基　　金：淄博市医药卫生科研项目(项目编号:20231503102)。

摘　　要：目的探讨养血生发汤联合复方倍他米松注射液治疗斑秃的临床疗效。方法100例斑秃患者,按照随机数字表法分为对照组和治疗组,各50例。对照组采用复方倍他米松注射液治疗,治疗组采用养血生发汤联合复方倍他米松注射液治疗。比较两组临床疗效,毛发生长情况,脱发面积和部位评分、轻拉发实验评分和皮肤病生活质量指数量表(DLQI)评分,免疫功能,不良反应和复发率。结果治疗组治疗总有效率96.00%高于对照组的84.00%(P<0.05)。治疗后,两组脱发区毛发再生情况、新生毛发密度、新生毛发粗细、新生毛发色泽评分均低于治疗前,且治疗组脱发区毛发再生情况、新生毛发密度、新生毛发粗细、新生毛发色泽评分分别为(1.54±0.32)、(0.84±0.19)、(0.87±0.20)、(0.72±0.13)分,均低于对照组的(2.28±0.40)、(1.20±0.27)、(1.28±0.23)、(1.09±0.20)分(P<0.05)。治疗后,两组脱发面积和部位评分、轻拉发实验评分、DLQI评分均低于治疗前,且治疗组脱发面积和部位评分、轻拉发实验评分、DLQI评分分别为(0.51±0.12)、(0.51±0.10)、(3.48±0.72)分,低于对照组的(0.84±0.16)、(0.68±0.12)、(6.51±1.15)分(P<0.05)。治疗后,两组CD^4(+)、CD^8(+)水平均低于治疗前,且治疗组CD^4(+)(39.71±5.03)%、CD^8(+)(21.32±3.60)%均低于对照组的(42.90±5.87)%、(23.01±3.84)%(P<0.05)。两组不良反应发生率比较无差异(χ^(2)=1.042,P=0.307>0.05)。治疗结束后随访3个月,治疗组复发率2.00%(1/50)低于对照组的16.00%(8/50)(χ^(2)=5.983,P=0.014<0.05)。结论养血生发汤联合复方倍他米松注射液治疗斑秃安全有效,可促进患者毛发生长,改善其免疫功能,减少其复发,利于加速其康复进程。Objective To explore the clinical efficacy of Yangxue Shengfa decoction combined with compound betamethasone injection in the treatment of alopecia areata.Methods 100 patients with alopecia areata were divided into a control group and a treatment group according to the random numerical table,with 50 patients in each group.The control group was treated with compound betamethasone injection,while the treatment group was treated with Yangxue Shengfa decoction and compound betamethasone injection.The clinical efficacy,hair growth,hair loss area and site score,light hair-pulling test score,dermatology life quality index(DLQI)score,immune function,adverse reactions and recurrence rate were compared between the two groups.Results The total effective rate of the treatment group was 96.00%,which was higher than 84.00%of the control group(P<0.05).After treatment,the scores of hair regeneration in the hair loss area,new hair density,new hair thickness and new hair color in both groups were lower than those before treatment;the scores of hair regeneration in the hair loss area,new hair density,new hair thickness and new hair color in the treatment group were(1.54±0.32),(0.84±0.19),(0.87±0.20)and(0.72±0.13)points,which were lower than(2.28±0.40),(1.20±0.27),(1.28±0.23)and(1.09±0.20)points in the control group(P<0.05).After treatment,the hair loss area and site score,light hair-pulling test score and DLQI score in both groups were lower than those before treatment;the hair loss area and site score,light hair-pulling test score and DLQI score in the treatment group were(0.51±0.12),(0.51±0.10)and(3.48±0.72)points,which were lower than(0.84±0.16),(0.68±0.12)and(6.51±1.15)points in the control group(P<0.05).++After treatment,CD4 and CD8 levels in both groups were lower than++those before treatment;the treatment group had CD4 of(39.71±5.03)%and CD8 of(21.32±3.60)%,which were lower than(42.90±5.87)%and(23.01±3.84)%in the control group(P<0.05).There was no difference in the incidence of adverse reactions between the

关 键 词：斑秃 养血生发汤 复方倍他米松注射液 临床疗效 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]