氨氯地平联合贝那普利治疗高血压的效果观察  

Effect observation of amlodipine combined with benazepril in the treatment of hypertension

作　　者：马珍妮 MA Zhen-ni(Tianyang District Traditional Chinese Medicine Hospital,Baise 533600,China)

机构地区：[1]百色市田阳区中医医院,533600

出　　处：《中国现代药物应用》2024年第7期81-83,共3页Chinese Journal of Modern Drug Application

摘　　要：目的研究氨氯地平联合贝那普利治疗高血压的疗效。方法135例高血压患者,根据用药方式不同分为观察组(68例)和对照组(67例)。对照组给予氨氯地平口服治疗,观察组给予氨氯地平联合贝那普利口服治疗。比较两组血压控制优良率,血压、心率水平,用药不良反应发生率。结果观察组的血压控制优良率97.06%(66/68)高于对照组的83.58%(56/67),差异有统计学意义(P<0.05)。治疗前,两组收缩压、舒张压和心率对比差异无统计学意义(P>0.05);治疗后,两组收缩压、舒张压、心率均低于治疗前,且观察组收缩压(121.18±23.61)mm Hg(1 mm Hg=0.133 kPa)、舒张压(82.32±16.04)mm Hg、心率(69.53±13.55)次/min低于对照组的(130.27±25.19)mm Hg、(88.85±17.18)mm Hg、(76.46±14.79)次/min,差异有统计学意义(P<0.05)。两组用药不良反应发生率对比差异无统计学意义(P>0.05)。结论高血压患者采用氨氯地平联合贝那普利治疗能够控制患者的血压和心率水平,提升血压控制优良率,且保证用药安全,值得推荐。Objective To study the efficacy of amlodipine combined with benazepril in the treatment of hypertension.Methods A total of 135 patients with hypertension were divided into an observation group(68 cases)and a control group(67 cases)according to different medication methods.The control group was treated with amlodipine orally,and the observation group was treated with amlodipine combined with benazepril orally.The rate of excellent blood pressure control,blood pressure,heart rate level and incidence of adverse drug reactions were compared between the two groups.Results The excellent rate of blood pressure control in the observation group was 97.06%(66/68),which was higher than 83.58%(56/67)in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in systolic blood pressure,diastolic blood pressure and heart rate between the two groups(P>0.05).After treatment,the systolic blood pressure,diastolic blood pressure and heart rate in both groups were lower than those before treatment;the observation group had systolic blood pressure of(121.18±23.61)mm Hg(1 mm Hg=0.133 kPa),diastolic blood pressure of(82.32±16.04)mm Hg,and heart rate of(69.53±13.55)beats/min,which were lower than(130.27±25.19)mm Hg,(88.85±17.18)mm Hg,and(76.46±14.79)beats/min in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse drug reactions between the two groups(P>0.05).Conclusion The treatment of amlodipine combined with bennazepril in patients with hypertension can control the blood pressure and heart rate of patients,improve the excellent rate of blood pressure control,and ensure the safety of medication,which is worth recommending.

关 键 词：氨氯地平 贝那普利 高血压 心率 血压控制 

分 类 号：R544.1[医药卫生—心血管疾病]