基于FAERS某院β-内酰胺类抗生素的发热反应分析  

Analysis of febrile response to β-lactam antibiotics based on FAERS in a hospital

作　　者：姬莲花 朱娟[1] 付中华[2] JI Lian-hua;ZHU Juan;FU Zhong-hua(Emergency Department of Henan Provincial People’s Hospital,Zhengzhou 450003,China;Pharmacy Department of Henan Provincial People’s Hospital,Zhengzhou 450003,China)

机构地区：[1]河南省人民医院急诊医学部,郑州450003 [2]河南省人民医院药学部,郑州450003

出　　处：《医药论坛杂志》2024年第5期520-523,共4页Journal of Medical Forum

基　　金：河南省医学研究教育项目(Wjlx2020044)。

摘　　要：目的 利用数据库分析河南省人民医院β-内酰胺类抗生素的发热反应信号,为临床护理β-内酰胺类抗生素引起的药物热提供循证依据。方法 收集河南省人民医院β-内酰胺类抗生素品种并查阅其说明书,借助FAERA数据库挖掘这些药品的发热反应报告,采用报告比值比法(ROR)与比例报告比值法(PRR)对数据进行描述性分析。结果 我院β-内酰胺类抗生素共有20个品种,其中青霉素G、苄星青霉素、阿莫西林、阿莫西林克拉维酸、头孢克洛等5个品种的说明书未收录发热反应。在FAERS数据库中检索到123 142份不良事件报告,其中发热反应5275份。经分析,青霉素类、头孢菌素类、碳青霉烯类与发热反应的PRR值分别是3.44、3.56、3.85,统计学上有显著的相关性,其中PRR值前5药品依次是头孢唑肟(17.06)、哌拉西林他唑巴坦(5.40)、美罗培南(4.17)、头孢曲松(3.69)、头孢他啶(3.63)。结论 不同的β-内酰胺类抗生素与发热反应的相关性强度有差别,并且与其说明书收录不完全一致,在临床实践中应加强药物致发热的鉴别与护理,保障患者安全。Objective To analyze the signals of fever response toβ-lactam antibiotics in our hospital by using the data⁃base,and to provide evidence-based basis for clinical nursing of drug fever caused byβ-lactam antibiotics.Methods The types ofβ-lactam antibiotics in our hospital were collected and their instructions were reviewed.The fever reaction reports of these drugs were mined with the help of FAERA database,and the data were descriptively ana⁃lyzed by reporting odds ratio(ROR)and proportion reporting ratio(PRR).Results There were 20 varieties ofβ-lac⁃tam antibiotics in our hospital,of which 5 varieties(penicillin G,benzathine penicillin,amoxicillin,amoxicillin clavu⁃lanic acid and cefaclor)did not include fever reaction in the instructions.A total of 123142 adverse event reports were retrieved from the FAERS database,including 5275 febrile reactions.The PRR values of penicillins,cephalosporins,and carbapenems were 3.44,3.56,and 3.85,respectively.There was a statistically significant correlation between them.The top five PRR values were cefazoxime(17.06),piperacillin-tazobactam(5.40),meropenem(4.17),ceftriaxone(3.69)and ceftazidime(3.63).Conclusion Differentβ-lactam antibiotics have different correlation in⁃tensities with fever reactions,and they are not completely consistent with their instructions.In clinical practice,the i⁃dentification and nursing of drug-induced fever should be strengthened to ensure the safety of patients.

关 键 词：Β-内酰胺类抗生素 药物热 不良反应 发热护理 FAERS 

分 类 号：R441.3[医药卫生—诊断学]