近红外二区花菁染料在疾病应用中的研究进展  

Research Advances of NIR⁃ⅡCyanine Dyes in Disease Applications

作　　者：仇雨 沈之阳 丁海贞 景靳彭 陈洪敏 Qiu Yu;Shen Zhiyang;Ding Haizhen;Jing Jinpeng;Chen Hongmin(School of Public Health,State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine,Xiamen University,Xiamen 361102,Fujian,China)

机构地区：[1]厦门大学公共卫生学院分子疫苗学与分子诊断学国家重点实验室分子影像暨转化医学研究中心,福建厦门361102

出　　处：《中国激光》2024年第3期52-66,共15页Chinese Journal of Lasers

基　　金：国家自然科学基金(82172007,81771977);福建省杰出青年科学基金(2021J06007)。

摘　　要：由于具备组织散射少、穿透深度深、时空分辨率高等许多优势,近年来近红外二区(NIR-Ⅱ,1000~1700 nm)荧光成像在生物成像领域取得了显著的进展。基于花菁染料的有机荧光分子,具有荧光量子产率高、吸光系数高、合成过程相对简单、生物相容性好等优势,其在NIR-Ⅱ的荧光特性使其成为一类极具研究价值的分子探针,在医学应用方面展现出巨大的潜力。首先简要介绍了花菁染料的基本特性,其次对最近开发的近红外二区花菁染料在多种疾病(如肿瘤、炎症性疾病和损伤)应用中的最新研究进展进行总结,最后对其未来的发展方向与前景进行了展望。Significance In recent years,the rapid development of bioimaging technology has provided powerful tools for life science research.Among them,fluorescence imaging,as an important imaging technique,enables real-time and non-invasive visualization of physiological activities in biological systems.Since biological tissues have lower absorption and scattering of photons in the nearinfrared regionⅡ(NIR-Ⅱ),combined with the weaker autofluorescence of tissues in this region,the signal-to-background ratio is greatly improved.Therefore,NIR-Ⅱfluorescence imaging can achieve deeper and higher-resolution biological imaging,and is expected to be widely used as an ideal precision imaging technique in basic research and clinical practice in the future.NIR-Ⅱfluorescence probes can be mainly categorized into inorganic and organic probes.Organic probes have advantages such as strong near-infrared absorbance,good biocompatibility,and easy metabolism,making them the preferred choice for in vivo imaging.Currently,there are two major classes of organic probes used in NIR‐Ⅱfluorescence imaging.One class is dyes with a donoracceptor-donor structure,and the other class is cyanine dyes connected by conjugated polymethyl chains with a certain length of carbon atoms.Compared with donor-acceptor-donor dyes,the synthesis process of NIR-Ⅱcyanine dyes is relatively simple,and they have higher brightness,thus possessing significant advantages in NIR-Ⅱimaging.Cyanine dyes,as a highly valuable class of molecular probes,exhibit excellent fluorescence characteristics in the NIR-Ⅱregion,so that they have attracted extensive research interests and continue to develop in the field of disease diagnosis and treatment.Due to the high tissue penetration depth and low interference from biological background signals,NIR‐Ⅱcyanine dyes can overcome the drawbacks of traditional fluorescence probes and be applied in the diagnosis of diseases.Cancer is one of the leading causes of death of the global population,characterized by high mortality

关 键 词：医用光学 花菁染料 近红外二区 疾病应用 

分 类 号：R445[医药卫生—影像医学与核医学]