近红外二区荧光金纳米团簇用于生物医学光子学:进展与挑战  

NIR⁃ⅡFluorescent Gold Nanoclusters for Biomedical Photonics:Advances and Challenges

作　　者：李丝雨 田方正 高笃阳 胡德红 郑海荣[2] 盛宗海 居胜红[1] Li Siyu;Tian Fangzheng;Gao Duyang;Hu Dehong;Zheng Hairong;Sheng Zonghai;Ju Shenghong(Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging&Interventional Radiology,Southeast University,Nanjing 210009,Jiangsu,China;Key Laboratory of Medical Imaging Science and Technology Systems,Paul C.Lauterbur Research Center for Biomedical Imaging,Institute of Biomedical and Health Engineering,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,Guangdong,China)

机构地区：[1]东南大学智能影像与介入医学国家级重点实验室培育建设点,江苏南京210009 [2]中国科学院深圳先进技术研究院生物医学与健康工程研究所劳伯特生物医学成像研究中心医学成像科学与技术系统重点实验室,广东深圳518055

出　　处：《中国激光》2024年第3期116-126,共11页Chinese Journal of Lasers

基　　金：国家自然科学基金(92159304,82171958,82372022,82227806,82027803,81927807,92159304,92059202);国家重点研发计划(2021YFA1101304);广东省科技计划项目(2023B1212060052);广东省基础与应用基础研究基金(2022A1515010384);深圳市医学研究基金(B2302021);深圳市科技重点专项(JCYJ20200109114612308,JCYJ20210324120011030)。

摘　　要：近红外二区(NIR-Ⅱ)金纳米团簇(Au NCs)具有明亮的多色荧光、良好的生物相容性和可肾脏清除的特性,已成为当前生物医学光子学领域中备受关注的纳米材料。首先介绍了NIR-ⅡAu NCs的合成方法,讨论了其面临的低产率和缺乏规模化制备的问题。其次,介绍了NIR-ⅡAu NCs的表面调控技术,讨论了调控团簇表面结构、组成和形态的方法,以及增大发光波长和提高荧光量子产率的方法。然后,总结了NIR-ⅡAu NCs在血管成像、淋巴管和淋巴结成像、肿瘤成像以及成像引导治疗等方面的最新研究进展。最后,讨论了NIR-ⅡAu NCs在生物医学光子学领域中面临的机遇与挑战。Significance Recently,fluorescence imaging in the second near-infrared window(NIR-Ⅱ,1000‒1700 nm)has attracted widespread attention from researchers.Compared with visible light window(300‒550 nm)and first near-infrared window(NIR-I,600‒950 nm)imaging,NIR-Ⅱfluorescence imaging exhibits unique advantages such as high tissue penetration(on the order of centimeters),high resolution(on the order of nanometers),and low background.NIR‑Ⅱfluorescent gold nanoclusters(NIR‑ⅡAu NCs)represent a category of nano-materials with exceptional clinical translational potential.NIR‑ⅡAu NCs possess singular advantages of monomeric composition,stable performance,small size(<3 nm),and renal clearance capability.They have been applied in various fields,including tumors,cardiovascular diseases,bacterial infections,neurosciences,and implantable medical devices,demonstrating significant potential applications and promising clinical translation prospects in the realm of high-sensitivity,high-resolution,and deeptissue molecular imaging of major disease biomarkers.Progress In this review,we initially introduce the synthesis methods of NIR-ⅡAu NCs,discussing the challenges of low yield and scalable production.Subsequently,we delve into the surface modulation techniques for NIR-ⅡAu NCs,and methods to regulate the cluster surface structure,composition,and morphology for enhancing their emission wavelengths and fluorescence quantum yields.We then summarize the latest research advancements of NIR‑ⅡAu NCs in vascular imaging,lymphatic vessel and lymph node imaging,tumor imaging,and imaging-guided therapy.Finally,we discuss the opportunities and challenges faced by NIR-ⅡAu NCs in the field of biomedical photonics.Conclusions and Prospects NIR‑ⅡAu NCs stand as potent candidates in the realm of biomedical photonics research,showcasing advantages of convenient synthesis,singular composition,tunable emission wavelength,good biocompatibility,in vivo clearance,and ease of targeted modification.They have demonstrated prom

关 键 词：生物光学 金纳米团簇 近红外二区荧光 生物医学光子学 生物成像 成像引导治疗 

分 类 号：O43[机械工程—光学工程]