益肾理血泄浊汤对慢性肾脏病-矿物质和骨紊乱患者的临床疗效  

Clinical effects of Yishen Lixue Xiezhuo Decoction on patients with chronic kidney disease-mineral and bone disorder

作　　者：童心 张静[2] 龚财判 冉茂霞 沈宏春 TONG Xin;ZHANG Jing;GONG Cai-pan;RAN Mao-xia;SHEN Hong-chun(College of Integrative Traditional Chinese Medicine and Western Medicine,Southwest Medical University·Department of Nephrology,The Affiliated Hospital of Traditional Chinese Medicine,Luzhou 646000,China;Department of Nephrology,Dazhou Municipal Central Hospital,Dazhou 635000,China)

机构地区：[1]西南医科大学中西医结合学院·附属中医医院肾脏内科,四川泸州646000 [2]达州市中心医院肾病内科,四川达州635000

出　　处：《中成药》2024年第4期1177-1181,共5页Chinese Traditional Patent Medicine

基　　金：四川省中医药管理局科学技术研究专项课题(2020LC0109)。

摘　　要：目的 考察益肾理血泄浊汤对慢性肾脏病-矿物质和骨紊乱患者的临床疗效。方法 116例患者随机分为对照组和观察组,每组58例,对照组给予常规治疗,观察组在对照组基础上加用益肾理血泄浊汤,疗程3个月。检测临床疗效、中医证候评分、肾功能指标(eGFR、BUN、Scr)、钙磷代谢指标(Ca、P、iPTH)、骨代谢指标(FGF23、TRACP、β-CTX)、安全性指标变化。结果 观察组总有效率高于对照组(P<0.05)。治疗后,2组中医证候评分、BUN、Scr、P、iPTH、骨代谢指标降低(P<0.05),eGFR、Ca升高(P<0.05),以观察组更明显(P<0.05)。2组未发现明显不良反应。结论 益肾理血泄浊汤可安全有效地改善慢性肾脏病-矿物质和骨紊乱患者临床症状和肾功能,调节钙磷代谢和骨代谢。AIM To investigate the clinical effects of Yishen Lixue Xiezhuo Decoction on patients with chronic kidney disease-mineral and bone disorder.METHODS One hundred and sixteen patients were randomly assigned into control group(58 cases)for 3-month intervention of conventional treatment,and observation group(58 cases)for 3-month intervention of both Yishen Lixue Xiezhuo Decoction and conventional treatment.The changes in clinical effects,TCM syndrome scores,renal function indices(eGFR,BUN,Scr),calcium-phosphorus metabolism indices(Ca,P,iPTH),bone metabolism indices(FGF23,TRACP,β-CTX)and safety indices were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05).After the treatment,the two groups displayed decreased TCM syndrome scores,BUN,Scr,P,iPTH,bone metabolism indices(P<0.05),and increased eGFR,Ca(P<0.05),especially for the observation group(P<0.05).No obvious adverse reactions were observable in the two groups.CONCLUSION For the patients with chronic kidney disease-mineral and bone disorder,Yishen Lixue Xiezhuo Decoction can safely and effectively improve clinical symptoms,renal functions,and regulate calcium-phosphorus metabolism,bone metabolism.

关 键 词：益肾理血泄浊汤 常规治疗 慢性肾脏病 矿物质和骨紊乱 

分 类 号：R287[医药卫生—中药学]