杭白菊木脂素类成分研究  

Lignans from Chrysanthemum morifolium

作　　者：杨鹏飞 刘华 张增辉 孙正光 黄申 钱玉梅 毛多斌 YANG Peng-fei;LIU Hua;ZHANG Zeng-hui;SUN Zheng-guang;HUANG Shen;QIAN Yu-mei;MAO Duo-bin(College of Tobacco Science and Engineering,Zhengzhou University of Light Industry,Zhengzhou 450002,China;Technology Center,Shaanxi Tobacco Industrial Co.,Ltd.,Xi’an 710000,China;Technology Center,Guangxi Tobacco Industrial Co.,Ltd.,Nanning 530000,China)

机构地区：[1]郑州轻工业大学烟草科学与工程学院,河南郑州450002 [2]陕西中烟工业有限责任公司技术中心,陕西西安710000 [3]广西中烟工业有限责任公司技术中心,广西南宁530000

出　　处：《中成药》2024年第4期1191-1195,共5页Chinese Traditional Patent Medicine

基　　金：国家自然科学基金项目(81903507)。

摘　　要：目的 研究杭白菊木脂素类成分。方法 采用大孔吸附树脂、Sephadex LH-20凝胶柱色谱和制备型HPLC对杭白菊80%乙醇提取物进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果 从中分离得到11个化合物,分别鉴定为ssioriside (1)、nudiposide (2)、lyoniside (3)、tortoside A (4), viburfordoside E (5)、tiliamuroside A (6)、开环异落叶松脂素-4-O-β-D-吡喃葡萄糖苷(7)、异落叶松脂醇-4-O-β-D-吡喃葡萄糖苷(8)、异落叶松脂醇-9-O-β-D-吡喃木糖苷(9)、5′-甲氧基-异落叶松脂醇-9′-O-β-D-吡喃木糖苷(10)、(7R,8R)-4,7,9,9′-四羟基-3,3′-二甲氧基-8-O-4′-新木脂素(11)。结论 化合物1~11均为首次从该植物中得到。AIM To study the chemical constituents of lignans from the flowers of Chrysanthemum morifolium Ramat..METHODS 80%ethanol extraction of C.morifolium flowers was isolated and purified by macroporous adsorption resin,Sephadex LH-20 and preparative HPLC,and structures of all obtained compounds were determined by their spectral data and physicochemical properties.RESULTS Eleven lignans were isolated and identified as ssioriside(1)、nudiposide(2)、lyoniside(3)、tortoside A(4),viburfordoside E(5)、tiliamuroside A(6)、secoisolariciresinol 4-O-β-D-glucopyranoside(7)、isolariciresinol 4-O-β-D-glucopyranoside(8)、isolariciresinol 9-O-β-D-xylocopyranoside(9)、5′-methoxy-isolariciresinol 9′-O-β-D-xylopyranoside(10)、(7 R,8R)-4,7,9,9′-tertahydroxy-3,3′-dimethoxy-8-O-4′-oxyneolignan(11).CONCLUSION All compounds are obtained from C.morifolium for the first time.

关 键 词：杭白菊 木脂素 分离鉴定 

分 类 号：R284.1[医药卫生—中药学]