胆木树干乙酸乙酯部位化学成分研究  

Chemical Constituents from Ethyl Acetate Fraction of the Trunk of Nauclea officinalis

作　　者：卢泰龙 邹正燃 李增光 林琳[1] 李硕果 范龙 LU Tai-long;ZOU Zheng-ran;LI Zeng-guang;LIN Lin;LI Shuo-guo;FAN Long(The Second Clinical College of Guangzhou University of Chinese Medicine,Guangzhou 510006,China;School of Chinese Materia Medica,Guangdong Pharmaceutical University,Guangzhou 510006,China;Hainan Institute for Food and Drug Control Haikou Branch,Haikou 570311,China)

机构地区：[1]广州中医药大学第二临床医学院,广东广州510006 [2]广东药科大学中药学院,广东广州510006 [3]海南省食品药品检验所海口分所,海南海口570311

出　　处：《中药材》2023年第9期2206-2209,共4页Journal of Chinese Medicinal Materials

摘　　要：目的:研究胆木Nauclea officinalis Pierre ex Pitard树干的化学成分。方法:采用硅胶柱、Sephadex LH-20葡聚糖凝胶和制备型高效液相等色谱技术对胆木树干95%乙醇提取物的乙酸乙酯部位进行分离纯化,根据理化性质及波谱数据鉴定化合物的结构。结果:从胆木树干乙酸乙酯部位中分离得到14个化合物,分别鉴定为:(6R,7E,9R)-9-hydroxy-4,7-megastigmadien-3-one(1)、(9S)-9-hydroxymegastigma-4,6E-dien-3-one(2)、blumenol C(3)、9-epi-blumenol C(4)、松柏醛(5)、3,5-二甲氧基-4-羟基苯甲醛(6)、芥子醛(7)、3,4-二甲氧基苯酚(8)、3,4,5-三甲氧基苯酚(9)、2-oxopomolic acid(10)、覆盆子酸(11)、桔皮晶(12)、(E)-3,3′-二甲氧基-4,4′-二羟基二苯乙烯(13)、fraxidin(14)。结论:其中,化合物2~8、10、11、13、14为首次从乌檀属植物中分离得到,化合物1、9、12为首次从胆木中分离得到。Objective:To study the chemical constituents from the trunk of Nauclea officinalis.Methods:The ethyl acetate fraction of the 95%ethanol extract from the trunk of Nauclea officinalis was isolated and purified by silica gel column chromatography,Sephadex LH-20 column chromatography and preparative high performance liquid chromatography,the structures were identified by physicochemical properties and spectral data.Results:Fourteen compounds were isolated from ethyl acetate fraction of the trunk of Nauclea officinalis and identified as(6R,7E,9R)-9-hydroxy-4,7-megastigmadien-3-one(1),(9S)-9-hydroxymegastigma-4,6E-dien-3-one(2),blumenol C(3),9-epi-blumenol C(4),coniferaldehyde(5),3,5-dimethoxy-4-hydroxybenzaldehyde(6),sinapaldehyde(7),3,4-dimethoxyphenol(8),3,4,5-trimethoxyphenol(9),2-oxopomolic acid(10),fupenzic acid(11),tangeretin(12),(E)-3,3′-dimethoxy-4,4′-dihydroxystilbene(13),fraxidin(14),respectively.Conclusion:Among them,compounds 2 to 8,10,11,13,14 are isolated from Nauclea genus for the first time,compounds 1,9,12 are isolated from Nauclea officinalis for the first time.

关 键 词：胆木 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]