SGLT-2抑制剂联合常规降糖治疗对2型糖尿病患者血管内皮功能的影响  

Effect of SGLT-2 inhibitor combined with conventional hypoglycemic therapy on vascular endothelial function in patients with type 2 diabetes

作　　者：张玉艳 Zhang Yuyan(The First People's Hospital of Pingyuan County,Dezhou,Shandong 253100)

机构地区：[1]平原县第一人民医院,山东德州253100

出　　处：《糖尿病天地》2024年第2期3-4,共2页Diabetes World

摘　　要：目的:研究2型糖尿病(T2DM)患者采用SGLT-2抑制剂与常规降糖联合治疗对其血管内皮功能的影响。方法:于2021年1月2022年12月,随机抽取我院T2DM患者60例作为对象,采用随机数字表法分组,对照组(n=30),施以常规降糖治疗,研究组(n=30),于对照组基础上联合使用SGLT-2抑制剂,观察治疗结果。结果:治疗后,组间FPG、2hPG水平对比研究组更低(P<0.05);组间NO比较研究组更高,而ET-1水平更低(P<0.05);组间药物安全性处于相当水平(P>0.05)。结论:T2DM患者于常规降糖治疗前提下,联合使用SGLT-2抑制剂更有利于其血管内皮功能改善,安全有效,值得推广。jObjective:To study the effect of SGLT-2 inhibitor combined with conventional antihyperglycemia therapy on vascular endothelial function in patients with type 2 diabetes(T2DM).Method:From January 2021 to December 2022,60 T2DM patients in our hospital were randomly selected as subjects and divided into odd and even number groups.The control group(n=30)received routine antihyperglycemia treatment,while the study group(n=30)received SGLT-2 inhibitor in combination with routine antihyperglycemia treatment.The treatment results were observed.Result:After treatment,the levels of FPG and 2hPG were lower in the study group compared to the control group(P<0.05);The NO levels between groups were higher in the study group,while the ET-1 levels were lower(P<0.05);The drug safety between groups was at a considerable level(P>0.05).Conclusion:Combining SGLT-2 inhibitors with conventional antihyperglycemia therapy is more beneficial for improving vascular endothelial function in T2DM patients,which is safe and effective and worth promoting.

关 键 词：2型糖尿病 SGLT-2抑制剂 常规降糖 血管内皮功能 

分 类 号：R587.1[医药卫生—内分泌]