基于古今医案云平台的《普济方》乳痈治疗用药规律研究  

Study on the medication law of treatment for acute mastitis in Pu Ji Fang based on the ancient and modern medical record cloud platform

作　　者：刘爽 张樱子 李宗友 Liu Shuang;Zhang Yingzi;Li Zongyou(Institute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Monitoring and Statistics Center,the State Administration of Traditional Chinese Medicine,Beijing 100027,China)

机构地区：[1]中国中医科学院中医药信息研究所,北京100700 [2]国家中医药管理局监测统计中心,北京100027

出　　处：《国际中医中药杂志》2024年第4期514-518,共5页International Journal of Traditional Chinese Medicine

基　　金：2019年全国中医药统计摘编编制(GCS-GHC-2020-001)。

摘　　要：目的分析《普济方》中治疗乳痈方剂的用药特点、组方规律,为现代中医临床治疗乳痈提供参考。方法筛选《普济方•妇人诸疾门》“乳痈”“妒乳”两部分中治疗乳痈的处方,运用古今医案云平台V2.3.5对处方数据进行用药频次、药性、药味、归经、功效分析,对高频用药进行聚类分析和关联规则分析。结果共纳入处方141首,涉及中药201种,使用频次排名前10位的药物依次为甘草、芍药、大黄、当归、黄芪、乳香、瓜蒌、人参、黄芩、皂角刺。用药药性以寒性为主,药味以甘味为主,归经以脾经为主,功效以清热解毒为主。对高频药物进行聚类分析可得3类,分别为人参-黄芪-当归-大黄、黄芩-芍药-甘草、瓜蒌-乳香-皂角刺。对高频药物进行关联分析,发现黄芪与芍药、当归、甘草、人参之间的关联性较大。结论《普济方》中乳痈的病机以湿热毒瘀、气血亏虚为主,治疗扶正重在补益肝脾气血,祛邪重在除湿清热解毒,化痰散结消瘀,另据病情,随症加减。Objective To analyze the medication characteristics and the rules of prescription for the treatment of acute mastitis in Puji Fang;To provide reference for the clinical treatment of acute mastitis in modern TCM.Methods Prescriptions of the chapters of"Ruyong"and"Duru"contained in Pu Ji Fang•Fu Ren Zhu Ji Men were screened,and the prescription data were analyzed by using the ancient and modern medical record cloud platform V2.3.5 for drug frequency,properties,tastes,meridian tropism,and efficacy.Clustering analysis of high-frequency drugs and analysis of association rules were performed.Results A total of 141 prescriptions were included,with 201 kinds of Chinese materia medica.The top ten drugs with the high frequency of use were Glycyrrhizae Radix et Rhizoma,Paeoniae Radix alba,Rhei Radix et Rhizoma,Angelicae Sinensis Radix,Astragali Radix,Olibanum,Trichosanthis Fructus,Ginseng Radix et Rhizoma,Scutellariae Radix,Gleditsiae Spina.The main property was cold,the main taste was sweet,the main meridian was spleen meridian,and the main efficacy was heat clearing and detoxification.Three types of high-frequency drugs could be obtained by clustering analysis,namely,Ginseng Radix et Rhizoma-Astragali Radix-Angelicae Sinensis Radix-Rhei Radix et Rhizoma,Scutellariae Radix-Paeoniae Radix alba-Glycyrrhizae Radix et Rhizoma,Trichosanthis Fructus-Olibanum-Gleditsiae Spina.Through correlation analysis of high-frequency drugs,it was found that there was a great correlation between Astragali Radix and Paeoniae Radix alba,Angelicae Sinensis Radix,Glycyrrhizae Radix et Rhizoma,Ginseng Radix et Rhizoma.Conclusions The pathogenesis of acute mastitis in Pu Ji Fang is mainly damp-heat toxin and blood stasis,and deficiency of qi and blood.The treatment for strengthening healthy qi focuses on tonifying qi and blood of the liver and spleen,while the treatment for eliminating pathogenic factors focuses on removing dampness,clearing heat and toxin,resolving phlegm,dispersing stasis and removing blood stasis.In addition,according to the c

关 键 词：乳痈 《普济方》 古今医案云平台 用药规律 数据挖掘 

分 类 号：R271.44[医药卫生—中医妇科学]