生命八要素评分与高尿酸血症的关联  

The association between the life's essential 8metrics and hyperuricemia

作　　者：李丽娜 杨文浩 杨静[1] 刘卓 杨文芳 吴寿岭[4] 崔刘福[1] LI Lina;YANG Wenhao;YANG Jing;LIU Zuo;YANG Wenfang;WU Shouling;CUI Liufu(Rheumatology and Immunology Department,Kailuan General Hospital,Tangshan,Hebei 063000,China;Rheumatology and Immunology Department,North China University of Science and Technology Affliated Hospital;Anesthesia Department,Union Medical Hospital of Tangshan;Cardiology Department,Kailuan General Hospital)

机构地区：[1]开滦总医院风湿免疫科,河北唐山063000 [2]华北理工大学附属医院风湿免疫科 [3]唐山市协和医院麻醉科 [4]开滦总医院心内科

出　　处：《中华高血压杂志（中英文）》2024年第3期262-270,共9页Chinese Journal of Hypertension

摘　　要：目的探索生命八要素评分与高尿酸血症的关联。方法采用横断面研究方法,以参加2006—2007年健康体检的开滦研究人群作为研究对象,排除生命八要素中任一项缺失和血尿酸水平缺失者,共纳入研究对象92912例,以修订后的生命八要素(吸烟、体育锻炼、饮食健康、体重指数、睡眠健康、血压、血糖和非高密度脂蛋白胆固醇)量表进行评分,并依据评分四分位进行分组。高尿酸血症定义为血尿酸≥420μmol/L。采用多因素logistic回归分析生命八要素评分与高尿酸血症的关联。结果在煤矿企业职工92912人中,男性占79.78%,平均年龄(51.5±12.6)岁,检出高尿酸血症5997例,检出率为6.45%。不同性别人群以生命八要素评分四分位数分组后合并为四组,多因素logistic回归分析结果显示,校正年龄、性别、婚姻状态、受教育程度、收入水平、饮酒、甘油三酯和估算的肾小球滤过率后,以生命八要素评分第1四分位组为参照,第2、3和4四分位组高尿酸血症风险分别降低9%(OR=0.91,95%CI 0.85~0.98,P=0.009)、26%(OR=0.74,95%CI 0.69~0.80,P<0.001)和36%(OR=0.64,95%CI 0.59~0.70,P<0.001)。生命八要素评分每增加1个标准差,高尿酸血症风险降低2%(OR=0.98,95%CI 0.98~0.99,P<0.001)。分层分析显示,以第1四分位组为参照,男性第2、3、4四分位组高尿酸血症风险分别降低6%(OR=0.94,95%CI 0.87~1.01)、23%(OR=0.77,95%CI 0.71~0.83)和32%(OR=0.68,95%CI 0.62~0.74),女性第2、3、4四分位组高尿酸血症风险分别降低27%(OR=0.73,95%CI 0.55~0.96)、40%(OR=0.60,95%CI 0.44~0.82)和55%(OR=0.45,95%CI 0.30~0.67)。以各年龄段生命八要素评分第1四分位组为参照,年龄<35、35~<45、45~<55、55~<65、≥65岁人群第4四分位组高尿酸血症风险分别降低47%(OR=0.53,95%CI 0.41~0.69)、45%(OR=0.55,95%CI 0.44~0.68)、32%(OR=0.68,95%CI 0.57~0.82)、37%(OR=0.63,95%CI 0.54~0.75)、25%(OR=0.75,95%CI 0.63~0.89)。结论生命八要素评分与高尿酸血症风�Objective To explore the association between the life's essential 8 metrics and hyperuricemia.Methods Using a cross-sectional study method,the Kailuan study population who participated in the health examination from 2006to 2007was selected as the research subjects.Excluding individuals with any deficiency in the eight elements of life and blood uric acid levels,a total of 92912subjects were included.The revised eight elements of life(smoking,physical exercise,dietary health,body mass index,sleeping health,blood pressure,blood sugar and non high-density lipoprotein cholesterol)scale was used for scoring.The subjects were grouped according to the quartile of the score.Hyperuricemia was defined as serum uric acid concentrations of≥420μmol/L for men and women.Association between the life's essential 8metrics and hyperuricemia was assessed using multiple logistic regression models.Results Among 92912coal mine enterprise workers,79.78%were male,with an average age of(51.5±12.6)years,and 5997cases of hyperuricemia were detected,with a detection rate of 6.45%.People of different genders were combined into four groups after grouping by quartiles of the score of the life's essential 8metrics.The results of multivariate logistic regression analysis showed that,after adjusted for age,gender,marital status,education level,income level,alcohol consumption,triglycerides,and estimated glomerular filtration rate,compared with the first quartile,the risk of hyperuricemia reduced by 9%(OR=0.91,95%CI 0.85-0.98,P=0.009),26%(OR=0.74,95%CI 0.69-0.80,P<0.001)and 36%(OR=0.64,95%CI 0.59-0.70,P<0.001)in the second,third,and fourth quartile groups,respectively.For each standard deviation increase in the score of the life's essential 8metrics,the risk of hyperuricemia reduced by 2%(OR=0.98,95%CI 0.98-0.99,P<0.001).Stratified analysis showed that compared with the first quartile,the risk of hyperuricemia in the second,third and fourth quartiles reduced by 6%(OR=0.94,95%CI 0.87-1.01),23%(OR=0.77,95%CI 0.71-0.83)and 32%(OR=0.68,95%CI 0.62-0

关 键 词：生命八要素 心血管健康 高尿酸血症 横断面研究 开滦研究 

分 类 号：R589.7[医药卫生—内分泌]