Do tensile and shear forces exerted on cells influence mechanotransduction through stored energy considerations?  

作　　者：FREDERICK H.SILVER TANMAY DESHMUKH 

机构地区：[1]Department of Pathology and Laboratory Medicine,Robert Wood Johnson Medical School,Rutgers,The State University of New Jersey,Piscataway,NJ 08854,USA [2]OptoVibronex,LLC.,Ben Franklin Tech Partners,Bethlehem,PA 18015,USA

出　　处：《BIOCELL》2024年第4期525-540,共16页生物细胞（英文）

摘　　要：All tissues in the body are subjected externally to gravity and internally by collagenfibril and cellular retractive forces that create stress and energy equilibrium required for homeostasis.Mechanotransduction involves mechanical work(force through a distance)and energy storage as kinetic and potential energy.This leads to changes in cell mitosis or apoptosis and the synthesis or loss of tissue components.It involves the application of energy directly to cells through integrin-mediated processes,cell-cell connections,stretching of the cell cytoplasm,and activation of the cell nucleus via yes-associated protein(YAP)and transcriptional coactivator with PDZ-motif(TAZ).These processes involve numerous complexes,intermediate molecules,and multiple pathways.Several pathways have been identified from research studies on vertebrate cell culture and from studies in invertebrates.These pathways involve mechanosensors and other molecules that activate the pathways.This review discusses the mitogen-activated protein kinase(MAPK)family,Hippo,Hedgehog,and Wingless-related integration site(WNT)/βcatenin signaling pathways.The mediators covered includeβcatenin,ion channels,growth factors,hormone receptors,members of the Ras superfamily,and components of the linker of nucleoskeleton and cytoskeleton(LINC)complex.However,the interrelationship among the different pathways remains to be clarified.Integrin-mediated mechanotransduction involves direct tensile loading and energy applied to the cell membrane via collagenfibril stretching.This energy is transferred between cells by stretching the cell-cell connections involving cadherins and the WNT/βcatenin pathway.These alterations induce changes in intracellular events in the cytoskeleton and nuclear skeleton caused by the release of YAP and TAZ.These coactivators then penetrate through the nuclear pores and influence nuclear cell function.Alteration in the balance of forces and energy applied to cells and tissues is hypothesized to shift the cell-extracellular matrix mechani

关 键 词：MAPK family HIPPO HEDGEHOG WNT pathway βcatenin Ion channels Growth factor receptors Hormone receptors Ras superfamily LINC complex COLLAGEN CADHERINS 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]