原发性甲状旁腺功能亢进症-棕色瘤-骨饥饿综合征  

Primary hyperparathyroidism-brown tumor-hungry bone syndrome

作　　者：贾觉睿智 刘宏颖 段炼 姜艳 李梅 夏维波 邢小平 王鸥 JIA-JUE Rui-zhi;LIU Hong-ying;DUAN Lian;JIANG Yan;LI Mei;XIA Wei-bo;XING Xiao-ping;WANG Ou(Department of Endocrinology,Peking Union Medical College Hospital,Chinese Academy of Medical Science&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院、北京协和医学院、北京协和医院内分泌科,卫健委内分泌重点实验室,北京100730

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2024年第1期50-55,共6页Chinese Journal Of Osteoporosis And Bone Mineral Research

摘　　要：骨饥饿综合征是原发性甲状旁腺功能亢进症术后不常见但较为严重的并发症,多见于术前骨骼受累严重者。本文报道了1例严重原发性甲状旁腺功能亢进症的45岁女性患者。患者术前骨痛明显,骨转换指标水平显著升高,影像学检查提示多发骨质破坏和棕色瘤等严重骨骼病变。患者在甲状旁腺病灶切除术后出现严重且持续的低钙血症,临床表现为口周和四肢麻木,考虑骨饥饿综合征,经大剂量钙和活性维生素D治疗,上述症状缓解,血钙恢复正常。Hungry bone syndrome is a relatively uncommon but severe postoperative complication of primary hyperparathyroidism,most frequently observed in patients with severe preoperative bone involvement.A 45-year-old female patient was diagnosed with severe primary hyperparathyroidism.The patient exhibited pronounced preoperative bone pain.Preoperative biochemical examinations revealed remarkedly elevated serum bone turnover markers,and imaging studies indicated multiple bone destruction and brown tumor.Following the surgical resection of parathyroid lesions,the patient developed a severe and persistent hypocalcemia,characterized by the perioral and limb paresthesia.Hungry bone syndrome was suspected,and the patient was treated with a high dose calcium and active vitamin D,resulting in symptoms alleviation and normalization of serum calcium levels.

关 键 词：原发性甲状旁腺功能亢进症 棕色瘤 骨饥饿综合征 

分 类 号：R582.1[医药卫生—内分泌]