生命早期肠道菌群异常参与发育源性骨质疏松症发生的研究进展  

Research progress on the involvement of gut microbiota dysbiosis in the developmental origin of osteoporosis in early life stage

作　　者：马翅 何航元 肖浩[1] 李斌[1] 汪晖[2,3] 陈廖斌 MA Chi;HE Hang-yuan;XIAO Hao;LI Bin;WANG Hui;CHEN Liao-bin(Department of Orthopedic Surgery,Zhongnan Hospital of Wuhan University,Wuhan 430071,China;Department of Pharmacology,Basic Medical School of Wuhan University,Wuhan 430071,China;Hubei Provincial Key Laboratory of Developmentally Originated Disease,Wuhan 430071,China)

机构地区：[1]武汉大学中南医院骨科,武汉430071 [2]武汉大学基础医学院药理学系,武汉430071 [3]发育源性疾病湖北省重点实验室,武汉430071

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2024年第1期75-80,共6页Chinese Journal Of Osteoporosis And Bone Mineral Research

基　　金：国家重点研发计划(2020YFA0803900)。

摘　　要：骨质疏松症(osteoporosis,OP)的发生与生命早期骨发育密切相关,是一种发育起源疾病。本文总结了OP发育起源相关的文献报道,提出其发生机制可能与生命早期肠道菌群异常有关。同时,简要阐明了生命早期肠道菌群的组成特征及其影响因素,并系统阐述了生命早期肠道菌群异常参与发育源性OP相关的临床与实验室研究。最后,鉴于生命早期肠道菌群在骨骼发育中的重要作用,从益生菌/益生元两方面总结生命早期干预肠道菌群策略对宿主生长发育及骨量的影响,为防治发育源性OP提供新思路与新策略。Osteoporosis(OP)is closely related to bone development in early life stage and regarded as a disease with developmental origin.The article summarized the literature about the developmental origin of OP and suggests that its occurrence mechanism may be related to gut microbiota dysbiosis in early life.Meanwhile,the characteristics of the composition of early-life gut microbiota and its influencing factors were briefly elucidated,and the clinical and laboratory studies related to the involvement of abnormal early-life gut microbiota in the developmental origin of OP were systematically described.Finally,given that the important role of early life gut microbiota in bone development,the article summarized the effects of early life gut microbiota intervention strategies on host growth,development and bone mass from both probiotics and prebiotics,to provide new ideas and strategies for the prevention and treatment of OP with developmental origin.

关 键 词：骨质疏松症 肠道菌群 生命早期 发育源性疾病 

分 类 号：R681.1[医药卫生—骨科学]