天然高分子自组装包埋单细胞在生物医学领域的应用  

Self-assembly of Natural Polymer-embedded Single Cells for Biomedical Applications

作　　者：贺斌 方一帆 成琳 郑旭磊 王科尧 朱兴 宋顺喜 HE Bin;FANG Yifan;CHENG Lin;ZHENG Xulei;WANG Keyao;ZHU Xing;SONG Shunxi(College of Bioresources Chemical and Materials Engineering,Shaanxi University of Science and Technology,Xi’an,Shaanxi Province,710021;National Demonstration Center for Experimental Light Chemistry Engineering Education,Xi'an,Shaanxi Province,710021)

机构地区：[1]陕西科技大学轻工科学与工程学院,陕西西安710021 [2]陕西科技大学轻化工程国家级实验教学示范中心,陕西西安710021

出　　处：《中国造纸学报》2024年第1期114-122,共9页Transactions of China Pulp and Paper

基　　金：国家自然科学基金(52003146,52103008);陕西省重点研发计划国际科技合作项目(2023-GHZD-14);陕西省科协青年人才托举计划(20210407);陕西省自然科学基础研究(2021JQ-541)。

摘　　要：利用层层自组装法制备天然高分子功能材料,具有操作简单、反应条件温和、壳层结构易调等特点,近年来已成为热点研究方向之一。基于此,本综述总结了利用淀粉、壳聚糖、海藻酸钠、明胶、纤维素等天然高分子,通过层层自组装法制备单细胞壳层的策略,讨论了自组装过程对细胞活性、pH耐受性等性能的影响,为固定化细胞在生物医学领域中的应用提供参考。Layer-by-Layer self-assembly method for preparation of natural polymer functionalized materials has emerged as a promising re-search direction in recent years,owing to its straight forward operation,gentle reaction conditions,and flexibility in adapting the shell layer structure.This review outlined the use of natural polymers like starch,chitosan,sodium alginate,gelatine,and cellulose to create single-cell shell layers through electrostatic Layer-by-Layer self-assembly.It also discussed the impact of the self-assembly process on the properties such as cell activity and pH tolerance,offering insight into the potential application of immobilized cells in biomedicine.

关 键 词：天然高分子 单细胞表面 层层自组装 壳层构筑 

分 类 号：TS7[轻工技术与工程—制浆造纸工程]