经验性抗真菌治疗在痰真菌涂片阳性的频繁急性加重慢阻肺患者的疗效观察  

Efficacy of empirical antifungal therapy in patients with chronic obstructive pulmonary disease with frequent acute exacerbation of sputum fungus smear-positive

作　　者：廖庆峰 章志俊 简佳庆 夏贤斌 潘冬青 何成 LIAO Qingfeng;ZHANG Zhijun;JIAN Jiaqing;XIA Xianbin;PAN Dongqing;HE Cheng(Department of Respiratory and Critical Care Medicine,Xinyu People's Hospital of Jiangxi Province,Xinyu City,Jiangxi Province,338000,China)

机构地区：[1]江西省新余市人民医院呼吸与危重症医学科,江西新余338000

出　　处：《蛇志》2024年第1期59-62,共4页Journal of Snake

基　　金：新余市科技计划项目(项目名称:伊曲康唑在痰真菌涂片阳性的频繁急性加重慢阻肺患者的疗效观察,项目编号:20223090884)。

摘　　要：目的探讨伊曲康唑在痰真菌涂片阳性的频繁急性加重慢阻肺(COPD)患者的疗效。方法选择2020年6月至2023年6月我院收治的频繁急性加重COPD患者90例,根据随机数字表法分为两组,每组45例。对照组使用氟康唑治疗,观察组予以伊曲康唑经验性抗真菌治疗,比较两组患者的治疗效果、肺功能、症状改善时间、再住院次数以及药物安全性。结果两组患者的药物安全性相当(P>0.05)。观察组的治疗效果优于对照组,治疗后的肺功能指标改善优于对照组,各项症状改善时间短于对照组,再住院次数少于对照组,差异均有统计学意义(均P<0.05)。结论痰真菌涂片阳性的频繁急性COPD患者口服伊曲康唑治疗的效果确切,可有效改善肺功能,缓解患者的临床症状,减少再住院次数,且不增加不良反应,安全性理想,值得临床应用。Objective To investigate the efficacy of itraconazole in patients with chronic obstructive pulmonary disease(COPD)with frequent acute exacerbation of sputum fungus smear-positive.Methods 90 patients with frequent acute exacerbation of COPD admitted to our hospital from June 2020 to June 2023 were selected and divided into two groups according to random number table method,with 45 cases in each group.The control group was given conventional antibiotics for anti-infection,antispasmodic and asthmatic treatment,and the observation group was given itraconazole on the basis of the control group.The therapeutic effect,lung function,symptom improvement time,re-hospitalization times and drug safety of the two groups were compared.Results The drug safety of the two groups was similar(P>0.05).The treatment effect of the observation group was better than that of the control group,the improvement of lung function index after treatment was better than that of the control group,the improvement time of symptoms was shorter than that of the control group,and the number of re-hospitalizations was less than that of the control group,the differences were statistically significant(P<0.05).Conclusion Oral itraconazole can effectively improve lung function,shorten clinical symptoms,reduce the number of re-hospitalizations,and do not increase obvious adverse reactions in patients with frequent acute COPD with positive sputum fungus smears.It is safe and worthy of clinical application.

关 键 词：频繁急性加重慢阻肺 伊曲康唑 痰真菌涂片阳性 

分 类 号：R379[医药卫生—病原生物学] R563[医药卫生—基础医学]